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Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies

for
Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
Location: Boston MA, Philadelphia PA, Baltimore MD, Columbus OH,
Sponsor: TopAlliance Biosciences

Sex: All

Age: 18+

Code: NCT04137900

Phase1, Recruiting

ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors

for
Advanced/Metastatic Solid Tumors
Location: Cleveland OH, Houston TX, Scottsdale AZ, Seattle WA,
Sponsor: Adagene Inc

Sex: All

Age: 18+

Code: NCT05405595

Phase1, Phase2, Recruiting

CT-95 in Advanced Cancers Associated With Mesothelin Expression

for
Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer,
Location: Hackensack NJ, Philadelphia PA, Grand Rapids MI,
Sponsor: Context Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06756035

Phase1, Recruiting

A Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors

for
Advanced/Metastatic Solid Tumors
Location: Fairfax VA, Pittsburgh PA, Ann Arbor MI, Houston TX,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT07141706

Phase1, Recruiting

Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors

for
Locally Advanced/Metastatic Solid Tumors
Location: New Haven CT, Indianapolis IN, Nashville TN, Denver CO,
Sponsor: InSilico Medicine Hong Kong Limited

Sex: All

Age: 18+

Code: NCT06414460

Phase1, Phase2, Recruiting

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A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors

for
Advanced Stage Solid Tumors
Location: New York NY, Fairfax VA, Sarasota FL, Nashville TN
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT07107230

Phase1, Recruiting

CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced / Metastatic Solid Tumors
Location: New York NY, Washington D.C. DC, Pittsburgh PA,
Sponsor: Crescent Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07335497

Phase1, Phase2, Recruiting

Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.

for
Small Cell Lung Cancer, Advanced Solid Malignant Tumor
Location: Boston MA, Fairfax VA, Canton OH, Detroit MI,
Sponsor: Chipscreen Biosciences, Ltd.

Sex: All

Age: 18+

Code: NCT05271292

Phase1, Phase2, Recruiting

CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

for
Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT05733000

Phase2, Recruiting

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

for
Advanced Cancer
Location: New York NY, Newark DE, Baltimore MD, Bethesda MD,
Sponsor: Riboscience, LLC.

Sex: All

Age: 18+

Code: NCT05270213

Phase1, Recruiting

A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors

for
Solid Tumor, Breast Cancer, Pancreatic Cancer, Ovarian Cancer,
Location: Huntersville NC, Detroit MI, Houston TX,
Sponsor: Qurgen Inc.

Sex: All

Age: 18+

Code: NCT05989724

Phase1, Recruiting

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for
Cancer
Location: New York NY, New Brunswick NJ, Philadelphia PA,
Sponsor: MBrace Therapeutics

Sex: All

Age: 18+

Code: NCT06014658

Phase1, Phase2, Recruiting

Phase I Study VG2025 as a Single Agent and in Combination Therapy With Nivolumab in Subjects With Advanced Malignant Solid Tumors

for
Solid Tumor
Location: Houston TX, Gilbert AZ
Sponsor: Virogin Biotech Canada Ltd

Sex: All

Age: 18+

Code: NCT05266612

Phase1, Recruiting

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

for
Advanced Cancer, Solid Tumor, Metastatic Cancer
Location: Miami FL, Omaha NE, Duarte CA
Sponsor: Proviva Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06190886

Phase1, Recruiting

A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors

for
Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer
Location: Boston MA, Canton OH, Detroit MI
Sponsor: Shanghai EpimAb Biotherapeutics Co., Ltd.

Sex: All

Age: 18+

Code: NCT03797391

Phase1, Phase2, Recruiting

First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

for
Solid Tumor, Adult
Location: Washington D.C. DC, Florida City FL, Huntersville NC,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT06554795

Phase1, Phase2, Recruiting

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

for
Esophageal Squamous Cell Carcinoma,
Location: Lake Success NY, Fairfax VA, Sarasota FL, Detroit MI,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18+

Code: NCT07503808

Phase1, Recruiting

Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors

for
Cancer, Solid Tumor Cancer, Advanced Metastatic Cancer,
Location: Fairfax VA, Plantation FL, Austin TX, San Antonio TX
Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07424547

Phase1, Recruiting

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

for
Lung Cancer (NSCLC), Prostate Cancer, Esophageal Cancer,
Location: Orlando FL, Nashville TN, Houston TX
Sponsor: Phrontline Biopharma

Sex: All

Age: 18+

Code: NCT07181473

Phase1, Recruiting

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

for
Solid Tumors
Location: New York NY, Virginia Beach VA, Bethesda MD,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT06953089

Phase2, Recruiting