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GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies

for
Hepatocellular Carcinoma, Hepatocellular Cancer,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT05003895

Phase1, Recruiting

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

for
Advanced Cancer, Metastatic Cancer, Ovarian Cancer,
Location: Lake Success NY, Philadelphia PA, East Syracuse NY,
Sponsor: Artios Pharma Ltd

Sex: All

Age: 18+

Code: NCT04657068

Phase1, Phase2, Recruiting

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

for
Locally Advanced or Metastatic ER+ HER2- Breast Cancer,
Location: New Haven CT, Edgewood KY, Louisville KY, Nashville TN,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT04606446

Phase2, Recruiting

Trial to Evaluate Safety, PD & PK of IV Study Drug, QN-302, in Pts w/ Advanced or Metastatic Solid Tumors

for
Solid Tumor
Location: Grand Rapids MI, Scottsdale AZ
Sponsor: Qualigen Theraputics, Inc.

Sex: All

Age: 18+

Code: NCT06086522

Phase1, Recruiting

BP1001-A in Patients With Advanced or Recurrent Solid Tumors

for
Solid Tumor, Adult, Carcinoma, Ovarian Epithelial,
Location: Silver Spring MD, Detroit MI, Houston TX, Dallas TX
Sponsor: Bio-Path Holdings, Inc.

Sex: All

Age: 18+

Code: NCT04196257

Phase1, Recruiting

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A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

for
Cancer, Cancer, Lung
Location: Lebanon NH, Philadelphia PA, Fairfax VA, Toronto,
Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05948865

Phase1, Recruiting

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

for
ER+ HER2- Advanced Breast Cancer,
Location: Providence RI, Nashville TN, St Louis MO, Houston TX
Sponsor: AstraZeneca

Sex: Female

Age: 18+

Code: NCT06188520

Phase1, Phase2, Recruiting

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

for
Solid Tumors
Location: Boston MA, New York NY, Hackensack NJ, Philadelphia PA,
Sponsor: Incyte Corporation

Sex: All

Age: 18+

Code: NCT06179160

Phase1, Recruiting

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

for
Solid Tumor, Non-Small Cell Lung Cancer, Head and Neck Cancer,
Location: Orange City FL, Clermont FL, Detroit MI, Atlanta GA,
Sponsor: Inhibrx Biosciences, Inc

Sex: All

Age: 18+

Code: NCT04198766

Phase1, Phase2, Recruiting

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for
Advanced Biliary Tract Carcinoma,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07405086

Recruiting

SB-4826 in Adult Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphomas

for
Non Hodgkin Lymphoma, Solid Tumor
Location: La Jolla CA
Sponsor: University of California, San Diego

Sex: All

Age: 18+

Code: NCT07222631

Phase1, Phase2, Recruiting

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

for
Advanced Breast Cancer, Metastatic Breast Cancer (HR+/ HER2-),
Location: New York NY, Long Island City NY, Grand Rapids MI,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07318805

Phase1, Recruiting

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

for
Small Cell Lung Carcinoma,
Location: Boston MA, Montreal, Royal Oak MI, Iowa City IA,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT07006727

Phase1, Recruiting

TLN-372 in Advanced KRAS Mutant Solid Tumors

for
KRAS Mutant Solid Tumors
Location: Boston MA, New York NY, Toronto, Grand Rapids MI,
Sponsor: Treeline Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT07204340

Phase1, Recruiting

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

for
Malignant Neoplasm
Location: Montreal, San Antonio TX
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07600749

Phase1, Recruiting

Clinical Trial of YH32367 in Patients With HER2 Positive Locally Advanced or Metastatic Solid Tumor

for
HER2-Positive Solid Tumor
Location: Boston MA, Nashville TN
Sponsor: Yuhan Corporation

Sex: All

Age: 18+

Code: NCT05523947

Phase1, Phase2, Recruiting

A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

for
Advance Solid Tumors
Location: Santa Monica CA
Sponsor: Kivu Bioscience Inc.

Sex: All

Age: 18+

Code: NCT07229313

Phase1, Recruiting

A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors

for
Solid Tumors
Location: New Brunswick NJ, Washington D.C. DC, Orlando FL,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT07123103

Phase1, Recruiting

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

for
Solid Tumor Cancer, Locally Advanced, Metastatic Solid Tumors,
Location: Washington D.C. DC, Sarasota FL, Atlanta GA, Houston TX,
Sponsor: Avenzo Therapeutics, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07038343

Phase1, Phase2, Recruiting

AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

for
Advanced Melanoma and Normal or Impaired, Advanced Melanoma
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT07027488

Phase1, Recruiting