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Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for
Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer,
Location: Boston MA, New York NY, Fairfax VA, Pittsburgh PA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06128551

Phase1, Phase2, Recruiting

Safety Study for a Gamma Delta T Cell Product Used With Low Dose Radiotherapy in Patients With Locally Advanced or Metastatic NSCLC or Solid Tumors With Bone Metastases

for
Carcinoma, Non-Small-Cell Lung Cancer,
Location: Norfolk VA, Pittsburgh PA, Tyler TX, Beverly Hills CA
Sponsor: Kiromic BioPharma Inc.

Sex: All

Age: 18+

Code: NCT06069570

Phase1, Recruiting

A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors

for
Solid Tumors, Adult
Location: Plantation FL, Cleveland OH, Denver CO
Sponsor: Hutchmed

Sex: All

Age: 18+

Code: NCT07228247

Phase1, Phase2, Recruiting

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

for
Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor,
Location: Boston MA, Baltimore MD, Bethesda MD, Toronto,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 12+

Code: NCT04924075

Phase2, Recruiting

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

for
Solid Tumor Cancer, Locally Advanced, Metastatic Solid Tumors,
Location: Boston MA, New York NY, Houston TX, Austin TX,
Sponsor: Avenzo Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07193511

Phase1, Phase2, Recruiting

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A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

for
Solid Tumors
Location: New Haven CT, Hackensack NJ, Los Angeles CA
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT05471856

Phase1, Recruiting

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for
Non-Small Cell Lung Cancer, NSCLC,
Location: Boston MA, New Haven CT, New York NY, Tampa FL,
Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All

Age: 18+

Code: NCT06917079

Phase1, Recruiting

Trial to Evaluate the Safety & Tolerability of JBZ-001 in Pts With Advanced Solid and Hematological Malignancies

for
Solid Tumor
Location: Columbus OH, West Valley City UT
Sponsor: Jabez Bioscience, Inc

Sex: All

Age: 18+

Code: NCT06801002

Phase1, Recruiting

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for
Non-small Cell Lung Cancer,
Location: Boston MA, New York NY, New Brunswick NJ, Pittsburgh PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05877599

Phase1, Recruiting

Clinical Nurse Specialist Led Early Palliative Survivorship Care for Patients With Advanced Cancer

for
Solid Tumor, Adult, Metastasis
Location: West Islip NY
Sponsor: Good Samaritan Hospital Medical Center, New York

Sex: All

Age: 21+

Code: NCT05947695

Recruiting

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

for
Advanced Cancer, Metastatic Solid Tumor
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 1 - 25

Code: NCT05004116

Phase1, Phase2, Recruiting

A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of BC3195 in Patients With Advanced or Metastatic Cancer

for
Advanced Cancer, Metastatic Solid Tumor
Location: Cleveland OH
Sponsor: Biocity Biopharmaceutics Co., Ltd.

Sex: All

Age: 18+

Code: NCT06548672

Phase1, Recruiting

High Dose Re-Irradiation Utilizing Advanced Deformable Image Registration (DIR) and Individualized Organ At Risk (OAR) Dose Calculations With Organ Specific Toxicity Analysis

for
Solid Tumor
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 18+

Code: NCT05301101

Recruiting

Safety and Tolerability Study of GIM-122 in Subjects With Advanced Solid Malignancies

for
Advanced Solid Malignancies
Location: New Brunswick NJ, Richmond VA, Sarasota FL,
Sponsor: Georgiamune Inc

Sex: All

Age: 18+

Code: NCT06028074

Phase1, Phase2, Recruiting

Cisplatin, Gemcitabine, Interferon Alfa, and Hyperthermia in Treating Patients With Advanced Cancer

for
Unspecified Adult Solid Tumor, Protocol Specific
Location: Houston TX
Sponsor: The University of Texas Health Science Center, Houston

Sex: All

Age: 18+

Code: NCT00004063

Phase1, Phase2, Recruiting

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

for
Solid Tumor, Adult, Triple Negative Breast Cancer,
Location: Scottsdale AZ, La Jolla CA, Stanford CA
Sponsor: BioEclipse Therapeutics

Sex: All

Age: 18+

Code: NCT04282044

Phase1, Recruiting

Study of STP938 (Dencatistat) in Advanced Solid Tumours

for
Solid Tumor
Location: St. Petersburg FL, Dallas TX, San Antonio TX
Sponsor: Step Pharma, SAS

Sex: All

Age: 18+

Code: NCT06297525

Phase1, Recruiting

A Study of EBC-129 in Advanced Solid Tumours

for
Advanced Solid Tumours
Location: Houston TX, Aurora CO
Sponsor: EDDC (Experimental Drug Development Centre), A*STAR Research Entities

Sex: All

Age: 18+

Code: NCT05701527

Phase1, Recruiting

A Study in People With Advanced Cancer to Test How Well Different Doses of BI 3819026 Are Tolerated When Taken Alone and Together With Ezabenlimab

for
Advanced Solid Cancer, Metastatic Solid Cancer
Location: New Haven CT, Nashville TN
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07607678

Phase1, Recruiting

Phase 1b Trial of BMS-986504 in Combination With Olaparib in Patients With MTAP Loss

for
Advanced Cancer, Solid Tumor
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07382544

Phase1, Recruiting