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An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumors
Location: Fairfax VA, Toronto, Pittsburgh PA, Huntersville NC,
Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All

Age: 18+

Code: NCT06480552

Phase1, Recruiting

A Study of TY-2136b in Patients With Advanced Solid Tumors Harboring ALK, ROS1 or NTRK1-3 Alterations

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Providence RI, Houston TX
Sponsor: TYK Medicines, Inc

Sex: All

Age: 18+

Code: NCT05769075

Phase1, Recruiting

A Study of ICP-192 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors, Urothelial Carcinoma, Cholangiocarcinoma
Location: Lake Success NY, Bronx NY, Columbus OH, Minneapolis MN,
Sponsor: Beijing InnoCare Pharma Tech Co., Ltd.

Sex: All

Age: 18+

Code: NCT04565275

Phase1, Phase2, Recruiting

Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Philadelphia PA, Kissimmee FL, Gainesville FL,
Sponsor: OncoC4, Inc.

Sex: All

Age: 18+

Code: NCT06352359

Phase1, Recruiting

A Phase 1/2, Study of YL-15293 in Subjects With Advanced Solid Tumors With a KRAS G12C Mutation

for
Advanced Solid Tumor
Location: Houston TX
Sponsor: Shanghai YingLi Pharmaceutical Co. Ltd.

Sex: All

Age: 18+

Code: NCT05119933

Phase1, Phase2, Recruiting

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Anti-GD2 ADC M3554 in Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, Houston TX
Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All

Age: 18+

Code: NCT06641908

Phase1, Recruiting

AIMS Cancer Outcomes Study

for
Neoplasms, Neoplasm Malignant, Advanced Cancer,
Location: Seattle WA
Sponsor: Advanced Integrative Medical Science Institute

Sex: All

Age: 0+

Code: NCT04495790

Recruiting

First in Human, Dose Escalation Study of AN4005

for
Advanced Solid Tumor, Advanced Lymphoma
Location: The Bronx NY, Hackensack NJ, Fairfax VA, Greenville SC
Sponsor: Adlai Nortye Biopharma Co., Ltd.

Sex: All

Age: 18+

Code: NCT04999384

Phase1, Recruiting

Dose Escalation and Expansion Study Evaluating ODC-IL2 in Adult Patients With Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumors, Metastatic Solid Tumors
Location: Scottsdale AZ
Sponsor: Trutino Biosciences Inc.

Sex: All

Age: 18+

Code: NCT06770764

Phase1, Recruiting

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

for
Non-Small Cell Lung Cancer, NSCLC,
Location: Boston MA, Westbury NY, New York NY, Washington D.C. DC,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06162221

Phase1, Phase2, Recruiting

Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.

for
Advanced Solid Tumor
Location: Boston MA
Sponsor: Oncomatryx Biopharma S.L.

Sex: All

Age: 18+

Code: NCT05547321

Phase1, Recruiting

SNV1521 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New Haven CT, Philadelphia PA, Toronto, Nashville TN,
Sponsor: Synnovation Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06220864

Phase1, Recruiting

A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors

for
Advanced Solid Tumor, NSCLC
Location: Lafayette IN, San Antonio TX, Spokane WA
Sponsor: Shanghai Huaota Biopharmaceutical Co., Ltd.

Sex: All

Age: 18+

Code: NCT05417321

Phase1, Phase2, Recruiting

A Study of LM-24C5 For Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Ocala FL
Sponsor: LaNova Medicines Limited

Sex: All

Age: 18+

Code: NCT06187402

Phase1, Phase2, Recruiting

Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Baltimore MD, Orlando FL, Columbus OH, Aurora CO,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06233942

Phase1, Recruiting

A Study of KK2269 in Adult Participants With Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor,
Location: Jacksonville FL, St Louis MO, Dallas TX, Scottsdale AZ,
Sponsor: Kyowa Kirin Co., Ltd.

Sex: All

Age: 18+

Code: NCT06266299

Phase1, Recruiting

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

for
Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
Location: Montreal, Ottawa, Kingston, Toronto, London, Regina,
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 18+

Code: NCT03297606

Phase2, Recruiting

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

for
Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors
Location: Boston MA, Providence RI, Mineola NY, New York NY,
Sponsor: Incyte Corporation

Sex: All

Age: 18+

Code: NCT05836324

Phase1, Recruiting

A Phase I First in Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of WGI-0301 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Baltimore MD, Whittier CA, Los Angeles CA
Sponsor: Zhejiang Haichang Biotech Co., Ltd.

Sex: All

Age: 18+

Code: NCT05267899

Phase1, Recruiting

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for
Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma
Location: Port Saint Lucie FL, Huntersville NC, Greenville SC,
Sponsor: FBD Biologics Limited

Sex: All

Age: 18+

Code: NCT05892718

Phase1, Recruiting