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A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

for
Locally Advanced Solid Tumors, Metastatic Solid Tumors
Location: Boston MA, Hollywood FL, Athens GA, Columbus OH,
Sponsor: Turning Point Therapeutics, Inc.

Sex: All

Age: 12+

Code: NCT03093116

Phase1, Phase2, Recruiting

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

for
Advanced Solid Tumor
Location: Boston MA, Montreal, Toronto, Pittsburgh PA, Tampa FL,
Sponsor: Senhwa Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT04890613

Phase1, Recruiting

A First-in-Human, Phase 1/2 Study of LAT010 in Patients with Advanced Solid Tumors (LIGHTSPEED-1)

for
Advanced Solid Tumor
Location: Margate FL
Sponsor: Latticon Antibody Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06277219

Phase1, Phase2, Recruiting

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for
Advanced Solid Tumors, HER2 Mutation
Location: Boston MA, Toronto, Fort Myers FL, Cleveland OH,
Sponsor: Bayer

Sex: All

Age: 18+

Code: NCT06760819

Phase2, Recruiting

Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New York NY, Houston TX, Irving TX,
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT06167317

Phase1, Recruiting

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A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors

for
HER-2 Positive Advanced Solid Tumors
Location: New York NY
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT05957536

Phase1, Recruiting

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

for
Advanced Solid Tumors, Metastatic Pancreatic Cancer,
Location: Bethesda MD, Fairway KS
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12 - 70+

Code: NCT04222413

Phase1, Recruiting

A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

for
Advanced Solid Tumors Cancer, MSI-H Cancer
Location: Providence RI, Fairfax VA, Charlottesville VA,
Sponsor: Nimbus Wadjet, Inc.

Sex: All

Age: 18 - 70+

Code: NCT06898450

Phase1, Phase2, Recruiting

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Philadelphia PA, Fairfax VA, Durham NC, Orlando FL,
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06108050

Phase1, Recruiting

Study of APR-1051 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Fairfax VA, Houston TX, Irving TX, San Antonio TX
Sponsor: Aprea Therapeutics

Sex: All

Age: 18+

Code: NCT06260514

Phase1, Recruiting

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for
Advanced Solid Tumor, Cutaneous Tumor, Subcutaneous Tumor,
Location: Boston MA, Bethesda MD, Toronto, Pittsburgh PA,
Sponsor: Ankyra Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06171750

Phase1, Recruiting

A Study of JNJ-87890387 for Advanced Solid Tumors

for
Neoplasms, Advanced Solid Tumors
Location: Grand Rapids MI, Nashville TN
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06178614

Phase1, Recruiting

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Fairfax VA, Grand Rapids MI, Irving TX, Austin TX,
Sponsor: Vividion Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06804824

Phase1, Recruiting

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06040541

Phase1, Recruiting

Dose-Escalation and Dose-Expansion Study of ZX-4081 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Huntersville NC
Sponsor: Nanjing Zenshine Pharmaceuticals

Sex: All

Age: 18+

Code: NCT05118841

Phase1, Recruiting

Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors

for
Advanced Solid Tumor, Malignant Solid Tumor
Location: Hackensack NJ, Sarasota FL, Denver CO
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT04145622

Phase1, Phase2, Recruiting

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

for
Advanced Solid Tumors
Location: Orange City FL, Lake City FL, Houston TX
Sponsor: Abion Inc

Sex: All

Age: 18+

Code: NCT05541822

Phase2, Recruiting

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, Fairfax VA, Plantation FL, Tamarac FL,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT05785741

Phase1, Phase2, Recruiting

A Study of PYX-201 in Advanced Solid Tumors

for
Solid Tumor, Advanced Solid Tumor
Location: Boston MA, Providence RI, New York NY, Philadelphia PA,
Sponsor: Pyxis Oncology, Inc

Sex: All

Age: 18+

Code: NCT05720117

Phase1, Recruiting

This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor
Location: Denver CO, San Antonio TX, Duarte CA, LA CA,
Sponsor: ABL Bio, Inc.

Sex: All

Age: 18+

Code: NCT04762641

Phase1, Recruiting