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A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

for
Locally Advanced Solid Tumors, Metastatic Solid Tumors,
Location: Scarborough ME, Boston MA, Montreal, Philadelphia PA,
Sponsor: Turning Point Therapeutics, Inc.

Sex: All

Age: 0 - 25

Code: NCT04094610

Phase1, Phase2, Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors

for
Advanced Cancer, Advanced Solid Tumor
Location: Fairfax VA, Margate FL
Sponsor: Shanghai Allink Biotherapeutics Co., Ltd.

Sex: All

Age: 18 - 70+

Code: NCT06707610

Phase1, Recruiting

First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors

for
Select Advanced Solid Tumors
Location: Philadelphia PA, Miami FL, Ann Arbor MI, Portland OR
Sponsor: CDR-Life AG

Sex: All

Age: 18+

Code: NCT06402201

Phase1, Recruiting

First in Human Study of UCT-03-008 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Dallas TX, Los Angeles CA
Sponsor: 1200 Pharma, LLC

Sex: All

Age: 18+

Code: NCT05103046

Phase1, Recruiting

SW-682 in Advanced Solid Tumors

for
Advanced Solid Tumor, Mesothelioma, Malignant
Location: Cleveland OH, Houston TX, Dallas TX, Scottsdale AZ,
Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Sex: All

Age: 18+

Code: NCT06251310

Phase1, Recruiting

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A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS

for
Advanced Solid Tumors
Location: Miami Beach FL, St. Petersburg FL, New Orleans LA
Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Sex: All

Age: 18+

Code: NCT05277168

Phase1, Phase2, Recruiting

Study of MTB-9655, an Inhibitor of ACSS2, in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Nashville TN
Sponsor: MetaboMed Inc

Sex: All

Age: 18+

Code: NCT04990739

Phase1, Recruiting

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors, HNSCC, SCLC, NSCLC,
Location: Boston MA, New York NY, New Haven CT, Miami FL, Toronto,
Sponsor: Tubulis GmbH

Sex: All

Age: 18+

Code: NCT06657222

Phase1, Phase2, Recruiting

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

for
Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma,
Location: Morristown NJ, Miami FL, Huntersville NC,
Sponsor: Aulos Bioscience, Inc.

Sex: All

Age: 18+

Code: NCT05267626

Phase1, Phase2, Recruiting

A Phase I Trial of SIM1811-03 in Subjects With Advanced Solid Tumors and Cutaneous T-cell Lymphoma

for
Advanced Solid Tumor, Cutaneous T-cell Lymphoma (CTCL)
Location: Huntersville NC
Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd.

Sex: All

Age: 18+

Code: NCT05569057

Phase1, Recruiting

First-in-Human Study of ATX-295, an Oral Inhibitor of KIF18A, in Patients With Advanced or Metastatic Solid Tumors, Including Ovarian Cancer

for
Advanced Solid Tumors, Breast Cancer Recurrent, Ovarian Cancer,
Location: New York NY, Fairfax VA, Sarasota FL, Detroit MI,
Sponsor: Accent Therapeutics

Sex: All

Age: 18+

Code: NCT06799065

Phase1, Recruiting

A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer

for
Advanced Solid Tumor, Metastatic Breast Cancer
Location: Lake Mary FL, Sarasota FL, Nashville TN, Houston TX
Sponsor: Edgewood Oncology Inc.

Sex: All

Age: 18+

Code: NCT04872166

Phase1, Recruiting

Clinical Trial of PM54 in Advanced Solid Tumors Patients.

for
Advanced Solid Tumor
Location: San Antonio TX
Sponsor: PharmaMar

Sex: All

Age: 18+

Code: NCT05841563

Phase1, Recruiting

XTX301 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New Haven CT, Hackensack NJ, Pittsburgh PA, Canton OH,
Sponsor: Xilio Development, Inc.

Sex: All

Age: 18+

Code: NCT05684965

Phase1, Phase2, Recruiting

Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, Ottawa, Fairfax VA, Toronto, San Antonio TX,
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT06532565

Phase1, Recruiting

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: Nuvalent Inc.

Sex: All

Age: 12+

Code: NCT05118789

Phase1, Phase2, Recruiting

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New York NY, New Brunswick NJ, Orlando FL,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT05932862

Phase1, Recruiting

Phase 1/2 Study of TU2218 Alone and in Combination With Checkpoint Inhibitors in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: San Antonio TX
Sponsor: TiumBio Co., Ltd.

Sex: All

Age: 18+

Code: NCT05204862

Phase1, Phase2, Recruiting

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

for
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC),
Location: North Haven CT, Lake Success NY, Chapel Hill NC,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06413680

Phase1, Phase2, Recruiting

Dose-escalation Study of Oral CX-4945

for
Advanced Solid Tumors, Breast Cancer,
Location: Houston TX, Fort Collins CO, Loveland CO, Scottsdale AZ
Sponsor: Cylene Pharmaceuticals

Sex: All

Age: 18+

Code: NCT00891280

Phase1, Recruiting