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A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Providence RI, Fairfax VA, Toronto, Sarasota FL,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT05765851

Phase1, Recruiting

FORTRAS: A Study of MSK-TCR5 in People With Solid Tumor Cancers

for
Solid Tumor, Solid Carcinoma, Advanced Solid Tumor,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07638371

Phase1, Recruiting

A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations

for
Advanced Solid Tumors With MAPK Pathway Mutations
Location: Detroit MI, Nashville TN, Houston TX
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT05886920

Phase1, Phase2, Recruiting

Dose-Escalation and Dose-Expansion Study of BSI-082 Monotherapy and Combined Therapy in Patients With Advanced or Metastatic Solid Tumors

for
Solid Tumor, Advanced Solid Tumor, Metastatic Solid Tumor
Location: San Antonio TX
Sponsor: Lei Zheng

Sex: All

Age: 18+

Code: NCT07086768

Phase1, Recruiting

A Study of Mutant Selective-Inhibitor (CGT6297), in Patients With Advanced Solid Tumors

for
PIK3CA Mutations, Advanced Solid Tumors, Adult,
Location: Boston MA, East Brunswick NJ, Fairfax VA, Tampa FL,
Sponsor: Cogent Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT07383506

Phase1, Recruiting

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A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

for
Advanced Solid Tumor, Non-Small Cell Lung Cancer,
Location: Fairfax VA, Tampa FL, Sarasota FL
Sponsor: Blueprint Medicines Corporation

Sex: All

Age: 18+

Code: NCT07629960

Phase1, Phase2, Recruiting

A First-in-Human Study of BG-C0979 in Adults With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Hackensack NJ, St Louis MO, San Antonio TX
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT07414836

Phase1, Recruiting

A Trial to Investigate the Safety of E303 in Participants With Advanced Refractory Solid Tumors

for
Advanced Solid Tumors
Location: Fairfax VA, Scottsdale AZ
Sponsor: Samsung Bioepis Co., Ltd.

Sex: All

Age: 18+

Code: NCT07524348

Phase1, Recruiting

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

for
Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR),
Location: Westbrook ME, Toronto, Indianapolis IN, Nashville TN,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT07403721

Phase1, Recruiting

Study in Advanced Solid Tumor Patients

for
Advanced Solid Tumor
Location: Nashville TN, Houston TX, San Antonio TX,
Sponsor: Callio Therapeutics

Sex: All

Age: 18+

Code: NCT07300943

Phase1, Phase2, Recruiting

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

for
TP53 Y220C Mutation, Advanced Solid Tumors
Location: Orlando FL, Nashville TN, Dallas TX, San Antonio TX,
Sponsor: PMV Pharmaceuticals, Inc

Sex: All

Age: 18+

Code: NCT07372625

Phase1, Recruiting

Trial to Evaluate the Safety and Preliminary Efficacy of GEN1079 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: New Haven CT, Lake Success NY, Grand Rapids MI
Sponsor: Genmab

Sex: All

Age: 18+

Code: NCT07387068

Phase1, Recruiting

A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, New Haven CT, Baltimore MD, Birmingham AL,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT07226349

Phase1, Recruiting

BTM-3566 in Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Houston TX, San Antonio TX
Sponsor: Bantam Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07266285

Phase1, Recruiting

A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New Haven CT, Grand Rapids MI,
Sponsor: Ottimo Pharma Limited

Sex: All

Age: 18+

Code: NCT07266428

Phase1, Phase2, Recruiting

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

for
Advanced Solid Tumors
Location: Fort Myers FL, Houston TX
Sponsor: Amgen

Sex: All

Age: 18+

Code: NCT07172919

Phase2, Recruiting

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

for
Melanoma, Metastatic Melanoma, Advanced Solid Tumor,
Location: La Jolla CA
Sponsor: Replimune Inc.

Sex: All

Age: 18+

Code: NCT06887348

Recruiting

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

for
Cancer, Immunotherapy, Advanced Solid Tumors Cancer,
Location: Frederick MD, St Louis MO, Springfield MO,
Sponsor: Elephas

Sex: All

Age: 18+

Code: NCT07327489

Recruiting

A Study of YL242 in Subjects With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Sarasota FL, Grand Rapids MI, Nashville TN
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT07197827

Phase1, Phase2, Recruiting

STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study

for
Advanced Solid Tumor, Metastatic Cancer
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT07269080

Phase1, Recruiting