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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

for
Pancreatic Acinar Cell Carcinoma,
Location: Saint Johnsbury VT, Lebanon NH, Commack NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT04858334

Phase2, Recruiting

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

for
B-ALL, Hematologic Malignancy, Solid Tumor
Location: Philadelphia PA, Milwaukee WI, Memphis TN, Aurora CO,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 30

Code: NCT06579469

Recruiting

Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)

for
Diffuse Large B Cell Lymphoma (DLBCL)
Location: Montreal, Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06050694

Phase2, Recruiting

MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease

for
Sickle Cell Disease
Location: Cleveland OH
Sponsor: University of California, Irvine

Sex: All

Age: 14+

Code: NCT06853158

Recruiting

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Portland ME, Scarborough ME, South Portland ME,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT05624996

Phase3, Recruiting

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Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

for
Post Traumatic Stress Disorder
Location: Charleston SC, New Orleans LA, Houston TX, Phoenix AZ
Sponsor: United States Department of Defense

Sex: All

Age: 18+

Code: NCT06957067

Recruiting

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Columbus OH, Duarte CA
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05136846

Phase1, Recruiting

Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer

for
BRAF NP_004324.2:p.V600E, BRAF V600K Mutation Present,
Location: Columbus OH, Houston TX, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT03975231

Phase1, Recruiting

CD19x22 Chimeric Antigen Receptor T-cell Therapy (CAR T) in Pediatric B-ALL

for
B-cell Acute Lymphoblastic Leukemia
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 0 - 30

Code: NCT06559189

Phase1, Recruiting

Heat Therapy in Type 2 Diabetes

for
Type 2 Diabetes
Location: West Lafayette IN
Sponsor: Purdue University

Sex: All

Age: 55+

Code: NCT06596967

Phase1, Recruiting

A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

for
Non Small Cell Lung Cancer,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05657873

Phase2, Recruiting

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06323460

Phase2, Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

for
Extensive-Stage Small Cell Lung Cancer
Location: Durham NC, Roanoke VA, Orange City FL, Fort Myers FL,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06646276

Phase3, Recruiting

Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients

for
Acute Myocardial Infarction Type 1
Location: Indianapolis IN
Sponsor: Rohan Dharmakumar

Sex: All

Age: 18 - 70+

Code: NCT05604131

Phase2, Recruiting

A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)

for
Ovarian Cancer, Ovarian Carcinoma, Stage II Ovary Cancer,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Female

Age: 18+

Code: NCT05429970

Recruiting

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

for
Medulloblastoma, Childhood,
Location: Washington D.C. DC
Sponsor: Children's National Research Institute

Sex: All

Age: 1 - 30

Code: NCT06193759

Phase1, Recruiting

Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of Disease

for
Triple Negative Breast Cancer, Non Small Cell Lung Cancer,
Location: Hartford CT, Commack NY, Norwalk CT, Uniondale NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT03808337

Phase2, Recruiting

Locally Ablative TherapY in Oligo-ProgressiVe GEnitourinary TumoRs (LAYOVER)

for
Prostate Cancer, Oligoprogressive, Urothelial Carcinoma,
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT06101290

Recruiting

Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer

for
Anatomic Stage I Breast Cancer AJCC v8,
Location: Cleveland OH, Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: Female

Age: 18+

Code: NCT05677802

Recruiting

Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers

for
Malignant Female Reproductive System Neoplasm,
Location: Baltimore MD, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03968406

Phase1, Recruiting