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Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Boston MA, Buffalo NY, Irvine CA, Duarte CA,
Sponsor: City of Hope Medical Center

Sex: All

Age: 70+

Code: NCT04305834

Phase2, Recruiting

Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or Nilotinib

for
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT01746836

Phase2, Recruiting

Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy

for
Lung Cancer, Nonsmall Cell
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT04691817

Phase1, Phase2, Recruiting

A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for
Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma,
Location: Boston MA, Hackensack NJ, Buffalo NY, Pittsburgh PA,
Sponsor: Regeneron Pharmaceuticals

Sex: Female

Age: 18+

Code: NCT06469281

Phase1, Recruiting

PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma

for
Metastatic Colorectal Cancer (Mcrc),
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT05286814

Phase2, Recruiting

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CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies

for
Hematologic Malignancy, ALL, Childhood, AML, Childhood,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT06326463

Phase1, Recruiting

Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia

for
Renal Failure Congenital, Congenital Renal Anomaly Nos,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 0+

Code: NCT03723564

Phase1, Recruiting

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

for
HPV-Associated Cervical Carcinoma, HPV-Related Carcinoma,
Location: New Brunswick NJ
Sponsor: Christian Hinrichs

Sex: All

Age: 18+

Code: NCT05639972

Phase1, Phase2, Recruiting

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

for
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Baltimore MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18+

Code: NCT06088381

Phase2, Recruiting

Role of the Immune Environment in Response to Therapy in Breast Cancer

for
Breast Cancer, ER Positive Breast Cancer,
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female

Age: 18+

Code: NCT05396612

Recruiting

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

for
Ovarian Cancer, Lung Adenocarcinoma, Endometrial Cancer,
Location: Boston MA, Providence RI, Montreal, Fairfax VA, Toronto,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT05797168

Phase1, Phase2, Recruiting

Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism

for
Hypothyroidism
Location: Besthesda MD
Sponsor: Walter Reed National Military Medical Center

Sex: All

Age: 18 - 65

Code: NCT02317926

Recruiting

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

for
Anatomic Stage 0 Breast Cancer AJCC v8,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: Female

Age: 18+

Code: NCT06401889

Recruiting

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

for
Solid Tumor, Advanced Cancer, Metastatic Cancer,
Location: Tampa FL
Sponsor: Memgen, Inc.

Sex: All

Age: 18+

Code: NCT05076760

Phase1, Recruiting

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma,
Location: Jacksonville FL, Grand Forks ND
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05969860

Phase2, Recruiting

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

for
Breast Carcinoma, Esophageal Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT00991094

Recruiting

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

for
Melanoma (Skin Cancer),
Location: Lake Success NY, Fairfax VA, Detroit MI, Cincinnati OH,
Sponsor: Aminex Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07287917

Phase1, Phase2, Recruiting

Pomalidomide After CAR T-cell Therapy for the Treatment of Relapsed or Refractory CD19+ B-cell Leukemia or Lymphoma

for
Recurrent B Acute Lymphoblastic Leukemia,
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 18+

Code: NCT07532525

Phase1, Recruiting

GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Relapsed/Refractory GPNMB-Expressing Solid Tumours

for
Alveolar Soft Part Sarcoma, Renal Cell Carcinoma,
Location: Toronto, Calgary
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 15+

Code: NCT07297667

Phase1, Recruiting

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

for
Anatomic Stage II Breast Cancer AJCC v8,
Location: West Islip NY, Stamford CT, New York NY, Millville DE,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07391774

Phase3, Recruiting