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Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy

for
Locally Advanced Cancer, Metastatic Cancer, HER2,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT06828588

Early_phase1, Recruiting

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

for
Breast Cancer, Metastatic Breast Cancer,
Location: New Haven CT, Baltimore MD, Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07340541

Phase2, Recruiting

A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors

for
Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma
Location: Fairfax VA, Louisville KY, Houston TX
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT07407933

Phase1, Phase2, Recruiting

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

for
Breast Neoplasms, Carcinoma, Ductal, Breast,
Location: Babylon NY, Jupiter FL, Jacksonville FL, Ocala FL,
Sponsor: Natera, Inc.

Sex: All

Age: 18+

Code: NCT07214532

Recruiting

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

for
NSCLC, NSCLC, Stage I, NSCLC Stage II,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07323732

Phase2, Recruiting

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Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06525766

Phase2, Recruiting

Asciminib as Maintenance Treatment After Cellular Therapies for Adults With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

for
B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07040982

Phase1, Recruiting

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment

for
Disease/Condition Name Cancer-related Cognitive Dysfunction,
Location: Rochester NY
Sponsor: University of Rochester NCORP Research Base

Sex: All

Age: 18+

Code: NCT07638007

Recruiting

Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial

for
Brain Metastases, Adult,
Location: Burlington VT
Sponsor: University of Vermont Medical Center

Sex: All

Age: 18+

Code: NCT06974370

Phase2, Recruiting

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

for
Medulloblastoma, Central Nervous System Embryonal Tumor,
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 1 - 30

Code: NCT07087002

Phase1, Recruiting

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

for
Solid Tumor Cancer, Locally Advanced, Metastatic Solid Tumors,
Location: Washington D.C. DC, Sarasota FL, Atlanta GA, Houston TX,
Sponsor: Avenzo Therapeutics, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07038343

Phase1, Phase2, Recruiting

Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms

for
Aneurysm, Stroke, Vasculitis, Tumor Necrosis Factor-alpha
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT02638701

Phase1, Phase2, Recruiting

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for
Ovarian Cancer, Fallopian Tube Cancer,
Location: Boston MA, Quebec, Greenfield Park, Montreal, Miami FL,
Sponsor: Regeneron Pharmaceuticals

Sex: Female

Age: 18+

Code: NCT06787612

Phase2, Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for
Advanced Malignant Solid Neoplasm,
Location: Brewer ME, Augusta ME, Scarborough ME,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0+

Code: NCT05564377

Phase2, Recruiting

Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

for
Central Nervous System Lymphoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05011045

Recruiting

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

for
Advanced Solid Tumor, Advanced Breast Cancer,
Location: Durham NC, Columbus OH, Nashville TN, Denver CO,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06120283

Phase1, Recruiting

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

for
Breast Cancer Female, Breast Cancer, Breast Cancer Metastatic,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT06439693

Phase2, Recruiting

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

for
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Durham NC, Charleston SC, St Louis MO, Houston TX
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT05793151

Recruiting

Stereotactic Magnetic Resonance Guided Radiation Therapy

for
Pancreas Cancer, Lung Cancer, Renal Cancer, Adrenal Metastases,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT04115254

Recruiting

PEARL (PrEnAtal Enzyme Replacement Therapy for Lysosomal Storage Disorders)

for
MPS I, MPS II, MPS IVA, MPS VI, Mps VII,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: Female

Age: 18 - 50

Code: NCT04532047

Phase1, Recruiting