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Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy

for
Breast Cancer, Hyperinsulinism, HER2-negative Breast Cancer
Location: New Haven CT
Sponsor: Yale University

Sex: Female

Age: 18+

Code: NCT05989347

Phase1, Recruiting

An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

for
Ovary Cancer, Peritoneal Cancer, Fallopian Tube Cancer
Location: Philadelphia PA, Pittsburgh PA, Chicago IL, Madison WI,
Sponsor: University of Colorado, Denver

Sex: Female

Age: 18 - 70+

Code: NCT05887609

Phase2, Recruiting

Clinical Study of ARD103 CAR-T Therapy for Patients With R/R AML or MDS

for
Acute Myeloid Leukemia, in Relapse,
Location: Winston-Salem NC, Charlotte NC, Houston TX
Sponsor: ARCE Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06680752

Phase1, Phase2, Recruiting

Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy

for
Prostate Cancer, Recurrent Prostate Cancer, PET Positive
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: Male

Age: 18 - 70+

Code: NCT06096870

Phase2, Recruiting

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for
Metastatic Renal Cell Carcinoma,
Location: Boston MA, Quebec, Bay Shore NY, Commack NY,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT05327686

Phase2, Recruiting

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A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

for
Invasive Ductal Breast Carcinoma,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05837767

Recruiting
FeaturedActive & Responsive

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

for
Generalized Anxiety Disorder (GAD)
Location: Cromwell CT, Springfield MA, Brooklyn NY, Toms River NJ,
Sponsor: AbbVie

Sex: All

Age: 18 - 65

Code: NCT06846320

Phase2, Recruiting
Featured

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

for
Immunoglobulin Light Chain (AL) Amyloidosis
Location: Boston MA, New York NY, Miami FL, Winston-Salem NC,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06158854

Phase1, Phase2, Recruiting
Featured

A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies

for
Gynecologic Cancers, Platinum-Sensitive Ovarian Cancer,
Location: Providence RI, Teaneck NJ, Fairfax VA, Cincinnati OH,
Sponsor: AbbVie

Sex: Female

Age: 18+

Code: NCT07024784

Phase2, Recruiting

Procurement of Blood Samples for a Biomedical Research Program on T Cell Functional Response to Chronic HBV Infection

for
Chronic Hepatitis B
Location: Richmond VA
Sponsor: Vaccine and Gene Therapy Institute, Florida

Sex: All

Age: 18+

Code: NCT02017587

Recruiting

Safety and Efficacy Study of INGN 241 Gene Therapy in Patients With In Transit Melanoma

for
Malignant Melanoma, Neoplasm Metastasis
Location: Houston TX
Sponsor: Introgen Therapeutics

Sex: All

Age: 18+

Code: NCT00116363

Phase2, Recruiting

Intrathecal Gene Therapy For SLC13A5 Citrate Transporter Disorder

for
SLC13A5 Citrate Transporter Disorder
Location: Dallas TX
Sponsor: TESS Research Foundation

Sex: All

Age: 2 - 20

Code: NCT07102524

Phase1, Phase2, Recruiting
New

Deucravacitinib-TNFi Combination Therapy for Difficult-to-Control Psoriatic Disease

for
Psoriatic Arthritis (PsA)
Location: Dallas TX
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18 - 65

Code: NCT07280702

Recruiting
New

A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1)

for
Small Cell Lung Cancer (SCLC ),
Location: New York NY, Hackensack NJ, Nashville TN, St Louis MO,
Sponsor: Moonlight Bio, Inc

Sex: All

Age: 18+

Code: NCT07488923

Phase1, Recruiting

Tafasitamab and Lenalidomide as First Salvage Therapy for Residual Large B Cell Lym

for
Large B-cell Lymphoma
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06760156

Phase2, Recruiting

Roux-en-Y-Gastric Bypass vs. Lifestyle Modification and Medical Therapy in the Treatment of Type 2 Diabetes

for
Type 2 Diabetes
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 21 - 65

Code: NCT01231308

Recruiting

Comparing 1 Week Versus 2 Week Cutaneous Suture Removal

for
Suture; Complications, Mechanical, Scar, Surgery
Location: Houston TX
Sponsor: DermSurgery Associates

Sex: All

Age: 18+

Code: NCT05267002

Recruiting

Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy

for
Diffuse Large B Cell Lymphoma
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05757219

Phase2, Recruiting

Improvement in Sleep Symptomatology and Neurocognitive Function Using Photobiomodulation in Post-Concussion Patients

for
Post-Concussion Syndrome, Sleep Disorder
Location: Toronto
Sponsor: Michael Zitney

Sex: All

Age: 18 - 70

Code: NCT05072743

Recruiting

Investigating the Use of Goal Management Therapy in Improving Cognitive Functioning in Public Safety Personnel With PTSD

for
Post Traumatic Stress Disorder, Cognitive Deficit
Location: Guelph
Sponsor: Homewood Research Institute

Sex: All

Age: 18 - 70

Code: NCT04251624

Recruiting