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Active & Responsive

Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC

for
Advanced Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma,
Location: New York NY, Indianapolis IN, St Louis MO, La Jolla CA
Sponsor: Karie Runcie

Sex: All

Age: 18+

Code: NCT06863311

Phase2, Recruiting
Active & Responsive

HER-2 B Cell Peptide Vaccine

for
Metastatic Breast Cancer, HER2-positive Breast Cancer,
Location: Indianpolis IN
Sponsor: Pravin T.P Kaumaya

Sex: All

Age: 18+

Code: NCT06414733

Phase1, Recruiting

CIBMTR Research Database

for
Autologous Stem Cell Transplantation,
Location: Milwaukee WI, Minneapolis MN
Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All

Age: 0+

Code: NCT01166009

Recruiting

Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning

for
Severe Combined Immunodeficiency, X Linked, Gene Therapy
Location: Boston MA, Atlanta GA, Cincinnati OH, Los Angeles CA
Sponsor: David Williams

Sex: Male

Age: 0 - 5

Code: NCT03311503

Phase1, Phase2, Recruiting

A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

for
Parkinson Disease
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: AskBio Inc

Sex: All

Age: 45 - 70+

Code: NCT06285643

Phase2, Recruiting

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HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

for
Glioblastoma Multiforme, Astrocytoma, Grade III
Location: Houston TX
Sponsor: David Baskin MD

Sex: All

Age: 18+

Code: NCT03596086

Phase1, Phase2, Recruiting

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

for
Glioblastoma, Anaplastic Astrocytoma
Location: Houston TX
Sponsor: The Methodist Hospital Research Institute

Sex: All

Age: 18+

Code: NCT03603405

Phase1, Phase2, Recruiting

A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

for
X-Linked Myotubular Myopathy
Location: Boston MA, Philadelphia PA, Toronto, Pittsburgh PA,
Sponsor: Astellas Gene Therapies

Sex: Male

Age: 0 - 17

Code: NCT06581146

Recruiting

A Study to Investigate the Safety and Biodistribution of a Single Intrathecal (IT) Injection of INS1201 in Ambulatory Males With Duchenne Muscular Dystrophy (DMD)

for
Duchenne Muscular Dystrophy
Location: Norfolk VA, Rochester NY, Columbus OH, Atlanta GA,
Sponsor: Insmed Gene Therapy LLC

Sex: Male

Age: 2 - 4

Code: NCT06817382

Phase1, Recruiting

Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need Ventilators

for
X-Linked Myotubular Myopathy
Location: Boston MA, Toronto, Chicago IL, Dallas TX, Portland OR
Sponsor: Astellas Gene Therapies

Sex: Male

Age: 0 - 3

Code: NCT07052929

Phase1, Phase2, Recruiting

JAG201 Gene Therapy Study in Children & Adults With SHANK3 Haploinsufficiency

for
SHANK3 Haploinsufficiency, Phelan-McDermid Syndrome
Location: Boston MA, New York NY, Chicago IL
Sponsor: Jaguar Gene Therapy, LLC

Sex: All

Age: 2 - 9

Code: NCT06662188

Phase1, Phase2, Recruiting

Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

for
Sensorineural Hearing Loss, Bilateral
Location: Boston MA, Philadelphia PA, Toronto, Cincinnati OH,
Sponsor: Akouos, Inc.

Sex: All

Age: 0+

Code: NCT05821959

Phase1, Phase2, Recruiting

Autologous Gene Therapy for Artemis-Deficient SCID

for
Severe Combined Immunodeficiency
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 0+

Code: NCT03538899

Phase1, Phase2, Recruiting

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

for
B-cell Acute Lymphoblastic Leukemia, Large B-cell Lymphoma,
Location: Valhalla NY, Chapel Hill NC, Jacksonville FL,
Sponsor: Vironexis Biotherapeutics Inc.

Sex: All

Age: 13 - 70+

Code: NCT06533579

Phase1, Phase2, Recruiting

Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.

for
Solid Tumor, Lymphoma
Location: Morristown NJ, Chicago IL
Sponsor: MultiVir, Inc.

Sex: All

Age: 18+

Code: NCT03544723

Phase2, Recruiting

A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)

for
Canavan Disease
Location: Boston MA, Chicago IL, Oakland CA
Sponsor: Aspa Therapeutics

Sex: All

Age: 0 - 2

Code: NCT04998396

Phase1, Phase2, Recruiting

Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU

for
Non Hodgkin Lymphoma,
Location: Boston MA, New Haven CT, Durham NC, Chicago IL,
Sponsor: Miltenyi Biomedicine GmbH

Sex: All

Age: 18+

Code: NCT06116110

Recruiting

A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

for
Duchenne Muscular Dystrophy
Location: Philadelphia PA, Norfolk VA, Toronto, Columbus OH,
Sponsor: Solid Biosciences Inc.

Sex: Male

Age: 0 - 17

Code: NCT06138639

Phase1, Phase2, Recruiting

Long-Term Follow up of Patients Undergoing Hematopoietic Stem Cell Transplantation, Cellular Therapy, or Gene Therapy

for
Cellular Immunotherapy, Adoptive, Genetic Therapy,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 4 - 70+

Code: NCT03000244

Recruiting

Long Term Follow-Up Study for Individuals With Hemoglobin Disorders After Hematopoietic Cell Transplant or Gene Therapy

for
Hemoglobin Disorder
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0+

Code: NCT06646640

Recruiting