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Active & Responsive

Super-Selective Intraarterial Intracranial Infusion of Bevacizumab (Avastin) for Glioblastoma Multiforme

for
Glioblastoma Multiforme
Location: Philadelphia PA
Sponsor: Global Neurosciences Institute

Sex: All

Age: 18+

Code: NCT02285959

Phase1, Recruiting
Active & Responsive

WBSI Guided Personalized Delivery of TTFields

for
GBM, Glioma Glioblastoma Multiforme, Tumor, Brain
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 22+

Code: NCT05086497

Recruiting
Active & Responsive

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

for
Glioblastoma Multiforme (GBM), Glioblastoma, Glioma of Brain,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18 - 70+

Code: NCT03213002

Phase1, Phase2, Recruiting
Active & Responsive

Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)

for
Glioblastoma Multiforme (GBM),
Location: Houston TX
Sponsor: Radiomedix, Inc.

Sex: All

Age: 18+

Code: NCT07733674

Phase1, Recruiting
Active & Responsive

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for
Glioblastoma (GBM), Newly Diagnosed Glioblastoma, GBM,
Location: Boston MA, New Haven CT, Lake Success NY, The Bronx NY,
Sponsor: Black Diamond Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07326566

Phase2, Recruiting

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Active & ResponsiveNew

NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors

for
Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma,
Location: Washington D.C. DC
Sponsor: Children's National Research Institute

Sex: All

Age: 3 - 25

Code: NCT07664176

Phase1, Recruiting
Active & ResponsiveNew

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

for
Newly Diagnosed Glioblastoma, Recurrent Glioblastoma
Location: Durham NC
Sponsor: Mustafa Khasraw, MBChB, MD, FRCP, FRACP

Sex: All

Age: 18+

Code: NCT04903795

Phase1, Recruiting
Active & Responsive

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for
Glioma, IDH Mutation, Astrocytoma, Oligodendroglioma
Location: Philadelphia PA
Sponsor: Stephen Bagley, MD, MSCE

Sex: All

Age: 18+

Code: NCT05345002

Phase2, Recruiting
Active & Responsive

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

for
Diffuse Midline Glioma (DMG), Glioblastoma,
Location: Philadelphia PA, Washington D.C. DC, Atlanta GA,
Sponsor: Sabine Mueller, MD, PhD

Sex: All

Age: 2 - 21

Code: NCT04732065

Phase1, Recruiting
Active & Responsive

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

for
Glioblastoma, IDH-Wildtype
Location: Durham NC, Winston-Salem NC, Morgantown WV,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT06319027

Phase2, Recruiting
Active & Responsive

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for
Glioma, Glioblastoma, Recurrent Glioma, Recurrent Glioblastoma,
Location: Iowa City IA
Sponsor: Kailin Yang, MD, PhD

Sex: All

Age: 18+

Code: NCT07541781

Phase1, Recruiting
Active & Responsive

Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

for
Glioblastoma (GBM), High Grade Gliomas, Recurrent Glioblastoma,
Location: Columbus OH
Sponsor: Trogenix ltd

Sex: All

Age: 18 - 70

Code: NCT07346144

Phase1, Phase2, Recruiting
Active & Responsive

The EASE Study: Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced Cancer

for
Advanced Solid Tumor Cancer,
Location: Aurora CO, Boulder CO
Sponsor: University of Colorado, Boulder

Sex: All

Age: 18+

Code: NCT07636200

Recruiting
Active & Responsive

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

for
AML (Acute Myeloid Leukemia), Glioma, Cholangiocarcinoma,
Location: New York NY, Orange CA
Sponsor: Rigel Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07486713

Recruiting
Active & Responsive

Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma

for
Glioblastoma
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06831526

Early_phase1, Recruiting
Active & Responsive

Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma

for
Glioblastoma
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07392957

Phase1, Phase2, Recruiting
Active & Responsive

First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 Astrocytoma

for
Astrocytoma, Glioblastoma, Progressive Disease
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18 - 70+

Code: NCT07560865

Phase1, Recruiting
Active & Responsive

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for
Glioma, Astrocytoma, Grade IV, IDH1-mutant Glioma,
Location: Boston MA, New Haven CT, New York NY, New Brunswick NJ,
Sponsor: Nuvation Bio Inc.

Sex: All

Age: 18+

Code: NCT05303519

Phase3, Recruiting
Active & Responsive

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

for
Glioma, Malignant
Location: Durham NC
Sponsor: Darell Bigner

Sex: All

Age: 18+

Code: NCT04547777

Phase1, Recruiting
Active & Responsive

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for
Glioblastoma
Location: Boston MA, New Haven CT, New York NY, Montreal,
Sponsor: Global Coalition for Adaptive Research

Sex: All

Age: 18+

Code: NCT03970447

Phase2, Phase3, Recruiting