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An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

for
WHO Grade 3 Glioma, WHO Grade 4 Glioma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06444412

Phase2, Recruiting

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

for
Glioma
Location: Hartford CT, Commack NY, Uniondale NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05188508

Phase2, Recruiting

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

for
IDH1 wt Allele, Recurrent Anaplastic Astrocytoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03896568

Phase1, Recruiting

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

for
Glioblastoma
Location: Sherbrooke, Montreal, Ottawa, Toronto, Hamilton,
Sponsor: NovoCure GmbH

Sex: All

Age: 18+

Code: NCT06556563

Phase3, Recruiting

A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions

for
High Grade Glioma, Glioblastoma
Location: Chandler AZ, Phoenix AZ
Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All

Age: 18+

Code: NCT06072586

Early_phase1, Recruiting

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Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

for
Glioblastoma, Gliosarcoma
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06934889

Phase1, Recruiting

Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors

for
High-grade Glioma, Solid Tumor, Unspecified, Child
Location: Edison NJ, Miami FL, Little Rock AR
Sponsor: Laminar Pharmaceuticals

Sex: All

Age: 0 - 18

Code: NCT04299191

Phase1, Phase2, Recruiting

Window of Opportunity Study of DSP-0390 in Gliomas

for
Glioma, Malignant, IDH Mutation
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06636162

Early_phase1, Recruiting

Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma

for
High Grade Glioma
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 10 - 70+

Code: NCT05632562

Early_phase1, Recruiting

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

for
High Grade Glioma, CNS Tumor
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 3

Code: NCT06528691

Phase2, Recruiting

Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252

for
Recurrent High Grade Glioma
Location: New York NY, Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT06126744

Phase1, Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma
Location: Boston MA, Montreal, Philadelphia PA,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 0 - 21

Code: NCT04655404

Early_phase1, Recruiting

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

for
EGFR Gene Mutation, Glioblastoma,
Location: San Francisco CA
Sponsor: Hideho Okada, MD, PhD

Sex: All

Age: 18+

Code: NCT06186401

Phase1, Recruiting

Tumor Treating Fields for the Treatment of Brainstem Gliomas

for
Glioma
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT05310448

Recruiting

Sacituzumab Govitecan in Recurrent Glioblastoma

for
Recurrent Glioblastoma
Location: Cleveland OH, Austin TX, San Antonio TX
Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All

Age: 18+

Code: NCT04559230

Phase2, Recruiting

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

for
Diffuse Intrinsic Pontine Glioma,
Location: Boston MA, Chicago IL, Orange CA
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All

Age: 1 - 18

Code: NCT04943848

Phase1, Recruiting

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

for
Astrocytoma, Glioma, Recurrent Glioblastoma
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06344130

Phase1, Recruiting

Study of Olutasidenib and Temozolomide in HGG

for
High Grade Glioma, Astrocytoma, Astrocytoma, Grade III,
Location: Durham NC, Miami FL, Columbus OH, Cincinnati OH,
Sponsor: Rigel Pharmaceuticals

Sex: All

Age: 12 - 39

Code: NCT06161974

Phase2, Recruiting

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

for
Glioblastoma, Recurrent Glioblastoma, Brain Tumor
Location: Boston MA
Sponsor: Ugonma Chukwueke

Sex: All

Age: 18+

Code: NCT06552260

Early_phase1, Recruiting

D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

for
Newly Diagnosed MGMT Unmethylated Glioblastoma
Location: Durham NC
Sponsor: Darell Bigner

Sex: All

Age: 18+

Code: NCT05734560

Phase1, Phase2, Recruiting