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Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab

for
Newly Diagnosed Glioblastoma
Location: New York NY, Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT06816927

Phase2, Recruiting

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

for
Recurrent Glioblastoma, IDH-Wildtype,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05789394

Phase1, Recruiting

F-Tryptophan PET/CT in Human Cancers

for
Intracranial Glioma, Metastatic Brain Tumor, Breast Cancer,
Location: Detroit MI
Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All

Age: 18+

Code: NCT05556473

Phase1, Recruiting

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

for
Glioma, Glioblastoma, Brain Tumor
Location: Bel Air MD, Glen Burnie MD, Baltimore MD, Columbia MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18+

Code: NCT04699773

Recruiting

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for
Glioblastoma
Location: Boston MA, New York NY, Pittsburgh PA
Sponsor: David Reardon, MD

Sex: All

Age: 18+

Code: NCT02977780

Phase2, Recruiting

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Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

for
Currently Only Enrolling Glioblastoma Patients at First Recurrence,
Location: Duarte CA, Stanford CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05139056

Phase1, Recruiting

Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

for
Diffuse Intrinsic Pontine Glioma, DIPG, Brain Tumor, CNS Tumor,
Location: Seattle WA
Sponsor: BrainChild Bio, Inc

Sex: All

Age: 1 - 26

Code: NCT07680439

Phase2, Recruiting

A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3

for
Glioma
Location: Nashville TN, Orange CA
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT05916313

Phase1, Recruiting

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

for
Neuroblastoma, Diffuse Intrinsic Pontine Glioma
Location: Hershey PA, Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 1 - 30

Code: NCT04837547

Phase1, Recruiting

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

for
Recurrent World Health Organization (WHO) Grade II Glioma,
Location: New York NY, Hackensack NJ, Philadelphia PA,
Sponsor: University of California, San Francisco

Sex: All

Age: 1 - 25

Code: NCT04485559

Phase1, Recruiting

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

for
Glioblastoma, Recurrent Glioblastoma, GBM
Location: New York NY, Baltimore MD, Chapel Hill NC, Miami FL,
Sponsor: CarThera

Sex: All

Age: 18+

Code: NCT05902169

Phase3, Recruiting

Music Therapy in Newly Diagnosed Glioblastoma After Chemoradiation Therapy (MELODY-GBM)

for
Glioblastoma (GBM)
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT07375992

Recruiting

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

for
Recurrent Glioblastoma
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 18 - 70+

Code: NCT06389591

Phase1, Recruiting

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

for
Brain Cancer, HGG, Glioma, High Grade Glioma,
Location: Nashville TN
Sponsor: Eben Rosenthal

Sex: All

Age: 18+

Code: NCT07210632

Early_phase1, Recruiting

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

for
Glioma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 3+

Code: NCT07076498

Phase1, Recruiting

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for
Recurrent Glioblastoma, IDH-Wildtype,
Location: New York NY, Livingston NJ, New Brunswick NJ,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05432804

Phase1, Phase2, Recruiting

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

for
Adult Glioblastoma, High Grade Glioma,
Location: Washington D.C. DC, Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 4+

Code: NCT04573140

Phase1, Recruiting

A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients

for
Glioblastoma (GBM)
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Myosin Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT07185880

Phase1, Phase2, Recruiting

T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas

for
Malignant Glioma
Location: Iowa City IA
Sponsor: John M. Buatti

Sex: All

Age: 21+

Code: NCT07447531

Recruiting

Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma

for
Glioblastoma
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 65+

Code: NCT07476794

Phase2, Recruiting