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Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

for
Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant,
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 3 - 39

Code: NCT06914479

Phase1, Recruiting

Venous Thromboembolism Prevention in Outpatients With Glioma

for
Glioblastoma, Astrocytoma, Venous Thromboembolism
Location: Burlington VT
Sponsor: University of Vermont Medical Center

Sex: All

Age: 18+

Code: NCT05683808

Phase2, Recruiting

Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma

for
Glioblastoma (GBM)
Location: Charlottesville VA
Sponsor: University of Virginia

Sex: All

Age: 18 - 70

Code: NCT07343986

Phase1, Recruiting

Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

for
High-grade Glioma, WHO Grade Ⅳ Glioma
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Tcelltech Inc.

Sex: All

Age: 18 - 70+

Code: NCT06482905

Phase1, Recruiting

Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas

for
High-Grade Glioma
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT06829173

Early_phase1, Recruiting

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Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

for
Glioblastoma
Location: Providence RI, Valhalla NY, Neptune City NJ,
Sponsor: GT Medical Technologies, Inc.

Sex: All

Age: 18+

Code: NCT07195591

Phase3, Recruiting

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

for
Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT05879250

Phase2, Recruiting

Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK

for
Pediatric Low-grade Glioma
Location: Quebec, Sherbrooke, Montreal, Toronto, London, Winnipeg,
Sponsor: St. Justine's Hospital

Sex: All

Age: 2 - 25

Code: NCT06666348

Phase1, Phase2, Recruiting

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

for
Glioblastoma, GBM
Location: Boston MA, Long Island City NY, New York NY, Albany NY,
Sponsor: Alpheus Medical, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07225621

Phase2, Recruiting

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

for
Recurrent Glioblastoma, Recurrent Gliomas
Location: New York NY, Columbus OH, Scottsdale AZ
Sponsor: Alpha Tau Medical LTD.

Sex: All

Age: 18 - 70+

Code: NCT06910306

Recruiting

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

for
BRAF V600 Mutation, Low-grade Glioma, Low Grade Glioma of Brain,
Location: Hackensack NJ, Baltimore MD, Washington D.C. DC,
Sponsor: University of California, San Francisco

Sex: All

Age: 1 - 25

Code: NCT07110246

Phase2, Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for
Diffuse Midline Glioma, H3 K27-Altered,
Location: Boston MA, Valhalla NY, New York NY, Philadelphia PA,
Sponsor: Children's Oncology Group

Sex: All

Age: 1 - 21

Code: NCT04870944

Phase1, Phase2, Recruiting

A Study of 177Lu-PSMA-617 in People With Gliomas

for
Glioma, Diffuse Astrocytoma, IDH-Wildtype (Grade 2-4),
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07223034

Phase1, Recruiting

Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma

for
Glioblastoma
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07145112

Phase1, Recruiting

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

for
Meningioma, Glioblastoma, Acoustic Neuroma, Brain Cancer,
Location: Nashville TN
Sponsor: Eben Rosenthal

Sex: All

Age: 18+

Code: NCT07493447

Early_phase1, Recruiting

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial

for
Glioma, Recurrent Glioma, Recurrent Glioblastoma
Location: Jacksonville FL, Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07074756

Recruiting

Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

for
Glioblastoma (GBM)
Location: South Weymouth MA, Boston MA, Milford MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 65+

Code: NCT06835803

Phase2, Recruiting

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

for
Glioblastoma, IDH-Wildtype, WHO Grade 4 Glioma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07091864

Recruiting

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

for
Recurrent Astrocytoma, IDH-Mutant, Grade 4,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07544992

Phase1, Recruiting

Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma

for
Recurrent Glioblastoma, IDH-Wildtype,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT06410248

Phase1, Recruiting