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Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC

for
Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC),
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT05414032

Phase2, Recruiting

Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC

for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC),
Location: Pittsburgh PA
Sponsor: Dan Zandberg

Sex: All

Age: 18+

Code: NCT06052839

Phase2, Recruiting
New

A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Tyler TX
Sponsor: Bicara Therapeutics

Sex: All

Age: 18+

Code: NCT07807163

Phase2, Recruiting

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

for
Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT05726370

Phase2, Recruiting

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for
Head and Neck Squamous Cell Carcinoma
Location: Boston MA, New York NY, Philadelphia PA, Baltimore MD,
Sponsor: Tempus AI

Sex: All

Age: 18+

Code: NCT06163534

Recruiting

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A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

for
Head and Neck Cancer, Head Cancer, Head Cancer Neck,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT04722523

Phase1, Recruiting

Single-Center Eval of Clinical & Radiological Benefit AHCC in Combo W/ SOC Tx for HPV+ Pts W/ HNSCC

for
HNSCC, Head and Neck Squamous Cell Carcinoma
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18 - 70+

Code: NCT06693323

Phase2, Recruiting

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for
Advanced/Metastatic Solid Tumors, Colorectal Cancer,
Location: Boston MA, New York NY, Philadelphia PA, Syracuse NY,
Sponsor: Merus B.V.

Sex: All

Age: 18+

Code: NCT03526835

Phase1, Phase2, Recruiting

A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC

for
Head and Neck Squamous Cell Carcinoma
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06597565

Phase2, Recruiting

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

for
Cutaneous Squamous Cell Carcinoma,
Location: Uniondale NY, New York NY, Middletown NJ, Montvale NJ,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05859074

Phase1, Recruiting

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

for
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT06239220

Phase2, Recruiting

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

for
Squamous Cell Carcinoma Head and Neck Cancer (HNSCC),
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT07149207

Phase2, Recruiting

Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma

for
Squamous Cell Carcinoma of Head and Neck,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06606028

Recruiting

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

for
Head and Neck Cancers- Squamous Cell, Head and Neck Cancer,
Location: Stanford CA
Sponsor: VLP Therapeutics

Sex: All

Age: 18+

Code: NCT06736379

Phase1, Recruiting

5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC

for
Squamous Cell Carcinoma of Head and Neck
Location: New Haven CT
Sponsor: Barbara Burtness

Sex: All

Age: 18+

Code: NCT05317000

Phase2, Recruiting

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

for
Solid Tumours, Sarcoma, HNSCC, Non Small Cell Lung Cancer,
Location: Houston TX, Beverly Hills CA, Santa Monica CA
Sponsor: Epkin

Sex: All

Age: 18+

Code: NCT06789172

Phase1, Recruiting

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors, HNSCC, SCLC, NSCLC,
Location: Boston MA, New York NY, New Haven CT, Miami FL, Toronto,
Sponsor: Tubulis GmbH

Sex: All

Age: 18+

Code: NCT06657222

Phase1, Phase2, Recruiting

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

for
NSCLC, HNSCC, Melanoma, Metastatic Cancer, Advanced Solid Tumor,
Location: Pittsburgh PA, Irvine CA
Sponsor: CJ Bioscience, Inc.

Sex: All

Age: 18+

Code: NCT05877430

Phase1, Phase2, Recruiting

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for
HNSCC, ESCC, Esophageal Adenocarcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New Haven CT, Hackensack NJ, Philadelphia PA,
Sponsor: Normunity AccelCo, Inc.

Sex: All

Age: 18+

Code: NCT07182149

Phase1, Recruiting

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

for
Squamous Cell Carcinoma of Head and Neck, Sinus Cancer,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07063212

Phase2, Recruiting