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Active & Responsive

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

for
Solid Tumor, Adult, Colorectal Cancer,
Location: New York NY, Jacksonville FL, Tampa FL, Columbus OH,
Sponsor: A2 Biotherapeutics Inc.

Sex: All

Age: 18+

Code: NCT04981119

Recruiting
Active & Responsive

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

for
Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer,
Location: Hartford CT, New York NY, Englewood NJ, Florham Park NJ,
Sponsor: VM Oncology, LLC

Sex: All

Age: 18 - 70+

Code: NCT03556228

Phase1, Phase2, Recruiting
Active & Responsive

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Providence RI, New York NY, Newark NJ,
Sponsor: Bicara Therapeutics

Sex: All

Age: 18+

Code: NCT06788990

Phase2, Phase3, Recruiting
Active & Responsive

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

for
Solid Tumor, Adult, Colorectal Cancer, Non-Small Cell Lung,
Location: New York NY, Jacksonville FL, Tampa FL, Columbus OH,
Sponsor: A2 Biotherapeutics Inc.

Sex: All

Age: 18+

Code: NCT06682793

Phase1, Phase2, Recruiting
Active & Responsive

177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

for
Castration-Resistant Prostate Cancer (CRPC), Colorectal Cancer,
Location: Dothan AL, Grand Rapids MI, Omaha NE
Sponsor: Radiopharm Theranostics, Ltd

Sex: All

Age: 18+

Code: NCT07189871

Phase1, Phase2, Recruiting

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Active & Responsive

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for
Solid Tumor Malignancies, Colorectal Carcinoma,
Location: Philadelphia PA, Fairfax VA, Orlando FL,
Sponsor: Tasca Therapeutics

Sex: All

Age: 18+

Code: NCT07030257

Phase1, Phase2, Recruiting

Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery

for
Head and Neck Cancer,
Location: Winston-Salem NC, Charlotte NC, Milwaukee WI
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06607406

Recruiting

Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC

for
Non-small Cell Lung Cancer(NSCLC),
Location: Fairfax VA
Sponsor: LG Chem

Sex: All

Age: 18+

Code: NCT06332755

Phase1, Recruiting

Window of Opportunity in Preserving Laryngeal Function Trial

for
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M),
Location: Pittsburgh PA
Sponsor: Matthew Spector

Sex: All

Age: 18+

Code: NCT07423078

Phase2, Recruiting

Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

for
Solid Tumor, Small Cell Lung Cancer (SCLC),
Location: Fort Worth TX, West Valley City UT, Los Angeles CA
Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT07517198

Phase1, Recruiting

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

for
Head and Neck Squamous Cell Carcinoma (HNSCC)
Location: Willow Grove PA, Richmond VA, Fairfax VA, Rochester NY,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06769698

Phase2, Recruiting

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

for
Renal Cell Carcinoma (RCC),
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT05176483

Phase1, Recruiting

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

for
Head and Neck Squamous Cell Carcinoma HNSCC,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Sutro Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07227168

Phase1, Recruiting

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

for
Head and Neck Squamous Cell Carcinoma (HNSCC),
Location: New York NY, Columbus OH, Grand Rapids MI,
Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT05985655

Phase1, Phase2, Recruiting

Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

for
Head and Neck Squamous Cell Carcinoma (HNSCC),
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT07465276

Phase2, Recruiting

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

for
Epidermal Growth Factor, Epidermal Growth Factor Receptor,
Location: Lake Success NY, East Brunswick NJ, Nashville TN,
Sponsor: EpiBiologics

Sex: All

Age: 18+

Code: NCT07462377

Phase1, Recruiting

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

for
Head and Neck Squamous Cell Carcinoma (HNSCC),
Location: Columbus OH, Grand Rapids MI, Houston TX,
Sponsor: Tanabe Pharma America, Inc.

Sex: All

Age: 18+

Code: NCT06943521

Phase1, Phase2, Recruiting

Head and Neck Squamous Cell Carcinoma (HNSCC)PET-CT Pilot Study

for
Head and Neck Squamous Cell Carcinoma
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT02678884

Recruiting

A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)

for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT07408063

Phase2, Recruiting

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

for
Hnscc, Head and Neck, Squamous Cell Cancer, Squamous Carcinoma,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT07460765

Phase1, Recruiting