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Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

for
Bladder Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18+

Code: NCT03740256

Phase1, Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for
Non-Small Cell Lung Cancer (NSCLC)
Location: Halifax, Worcester MA, Montreal, Media PA, Newark DE,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT05920356

Phase3, Recruiting

Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC

for
Non-Small Cell Lung Cancer
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT06088771

Phase1, Phase2, Recruiting

Safety and Immunogenicity of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Ocoee FL, Tyler TX, Dallas TX, Spokane WA, Seattle WA
Sponsor: Corixa Corporation

Sex: All

Age: 18+

Code: NCT00062907

Phase1, Recruiting

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

for
Metastatic Lung Non-Small Cell Carcinoma,
Location: Columbus OH
Sponsor: Dwight Owen

Sex: All

Age: 18+

Code: NCT05234307

Phase1, Recruiting

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Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases

for
Extensive-stage Small-cell Lung Cancer, Liver Metastases
Location: Ann Arbor MI, Los Angeles CA
Sponsor: Kamya Sankar

Sex: All

Age: 0+

Code: NCT05588388

Phase2, Recruiting

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for
Recurrent Lung Non-Small Cell Carcinoma,
Location: Brewer ME, Manchester NH, Worcester MA, Concord NH,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 0+

Code: NCT06031688

Phase2, Recruiting

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

for
Lung Cancer, Sarcoidosis
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT05171478

Recruiting

Engage Psychosocial Intervention for Cancer Symptoms

for
Advanced Breast Cancer, Advanced Prostate Cancer,
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT06555588

Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Melanoma, Head and Neck Cancer,
Location: New Haven CT, New York NY, Baltimore MD, Buffalo NY,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06172478

Phase2, Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for
Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive
Location: Boston MA, Westbury NY, New York NY, Sellersville PA,
Sponsor: Nuvalent Inc.

Sex: All

Age: 18+

Code: NCT06765109

Phase3, Recruiting

Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment

for
Non-Small Cell Lung Cancer
Location: Toronto, London
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All

Age: 18+

Code: NCT04852588

Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

for
Non-small Cell Lung Cancer (NSCLC)
Location: Westbrook ME, Mississauga, Brampton, Jacksonville FL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06170788

Phase3, Recruiting

Salivary Biomarkers for Non-small Cell Lung Cancer Detection

for
Lung Cancer
Location: Wynnewood PA, Warren MI
Sponsor: PeriRx

Sex: All

Age: 18+

Code: NCT02294578

Recruiting

REStoring lymphoCytes Using NKTR-255* After chemoradiothErapy in Solid Tumors (RESCUE)

for
Lung Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05632809

Phase2, Recruiting

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05010109

Recruiting

Niraparib in Combination With Osimertinib in EGFR-Mutated Advanced Lung Cancer

for
Lung Cancer
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT03891615

Phase1, Recruiting

Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06660407

Phase2, Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for
Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary,
Location: Providence RI, New Haven CT, New York NY, Baltimore MD,
Sponsor: Volastra Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05902988

Phase1, Phase2, Recruiting

Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients

for
Small Cell Lung Cancer Extensive Stage
Location: Fairfax VA, Canton OH, Cincinnati OH, Fairfield OH,
Sponsor: Genprex, Inc.

Sex: All

Age: 18+

Code: NCT05703971

Phase1, Phase2, Recruiting