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Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

for
Recurrent Glioblastoma, IDH-Wildtype,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05789394

Phase1, Recruiting

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

for
Recurrent Astrocytoma, IDH-Mutant, Grade 3,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06815029

Phase1, Recruiting

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for
Glioblastoma
Location: Boston MA, New York NY, Pittsburgh PA
Sponsor: David Reardon, MD

Sex: All

Age: 18+

Code: NCT02977780

Phase2, Recruiting

Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma

for
Glioblastoma, Glioblastoma Multiforme
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT05281731

Recruiting

Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

for
Currently Only Enrolling Glioblastoma Patients at First Recurrence,
Location: Duarte CA, Stanford CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05139056

Phase1, Recruiting

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Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

for
Glioblastoma, Recurrent Glioblastoma, GBM
Location: New York NY, Baltimore MD, Chapel Hill NC, Miami FL,
Sponsor: CarThera

Sex: All

Age: 18+

Code: NCT05902169

Phase3, Recruiting

Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

for
Astrocytoma, IDH-Mutant, Grade 3
Location: Bath ME, Portland ME, Scarborough ME, Sanford ME,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 12+

Code: NCT07215910

Phase3, Recruiting

Music Therapy in Newly Diagnosed Glioblastoma After Chemoradiation Therapy (MELODY-GBM)

for
Glioblastoma (GBM)
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT07375992

Recruiting

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

for
Recurrent Glioblastoma
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 18 - 70+

Code: NCT06389591

Phase1, Recruiting

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

for
Glioblastoma Multiforme, Glioblastoma
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 18 - 70+

Code: NCT05353530

Phase1, Recruiting

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for
Recurrent Glioblastoma, IDH-Wildtype,
Location: New York NY, Livingston NJ, New Brunswick NJ,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05432804

Phase1, Phase2, Recruiting

A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients

for
Glioblastoma (GBM)
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Myosin Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT07185880

Phase1, Phase2, Recruiting

Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.

for
Retinoblastoma Bilateral, Retinoblastoma Unilateral,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 0+

Code: NCT06725173

Recruiting

Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma

for
Glioblastoma
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 65+

Code: NCT07476794

Phase2, Recruiting

Venous Thromboembolism Prevention in Outpatients With Glioma

for
Glioblastoma, Astrocytoma, Venous Thromboembolism
Location: Burlington VT
Sponsor: University of Vermont Medical Center

Sex: All

Age: 18+

Code: NCT05683808

Phase2, Recruiting

Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma

for
Glioblastoma (GBM)
Location: Charlottesville VA
Sponsor: University of Virginia

Sex: All

Age: 18 - 70

Code: NCT07343986

Phase1, Recruiting

GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma

for
Glioblastoma Multiforme of Brain
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 21 - 70

Code: NCT06815432

Phase1, Recruiting

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

for
Glioblastoma
Location: Providence RI, Valhalla NY, Neptune City NJ,
Sponsor: GT Medical Technologies, Inc.

Sex: All

Age: 18+

Code: NCT07195591

Phase3, Recruiting

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

for
Glioblastoma, Brain Cancer, Glioblastoma Multiforme,
Location: New York NY, Miami FL
Sponsor: Baptist Health South Florida

Sex: All

Age: 18+

Code: NCT06991101

Phase2, Recruiting

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

for
Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT05879250

Phase2, Recruiting