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Active & Responsive

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for
Glioma, Glioblastoma, Recurrent Glioma, Recurrent Glioblastoma,
Location: Iowa City IA
Sponsor: Kailin Yang, MD, PhD

Sex: All

Age: 18+

Code: NCT07541781

Phase1, Recruiting
Active & Responsive

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

for
Glioma, Malignant
Location: Durham NC
Sponsor: Darell Bigner

Sex: All

Age: 18+

Code: NCT04547777

Phase1, Recruiting
Active & Responsive

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

for
Diffuse Midline Glioma (DMG), Glioblastoma,
Location: Philadelphia PA, Washington D.C. DC, Atlanta GA,
Sponsor: Sabine Mueller, MD, PhD

Sex: All

Age: 2 - 21

Code: NCT04732065

Phase1, Recruiting
Active & Responsive

WBSI Guided Personalized Delivery of TTFields

for
GBM, Glioma Glioblastoma Multiforme, Tumor, Brain
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 22+

Code: NCT05086497

Recruiting
Active & ResponsiveNew

A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

for
Pediatric Tumor of CNS, Pediatric Tumor of Brain,
Location: Orange CA
Sponsor: Neonc Technologies, Inc.

Sex: All

Age: 5 - 18

Code: NCT06357377

Phase1, Recruiting

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Active & ResponsiveNew

NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors

for
Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma,
Location: Washington D.C. DC
Sponsor: Children's National Research Institute

Sex: All

Age: 3 - 25

Code: NCT07664176

Phase1, Recruiting
Active & Responsive

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

for
Glioblastoma Multiforme (GBM), Glioblastoma, Glioma of Brain,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18 - 70+

Code: NCT03213002

Phase1, Phase2, Recruiting
Active & Responsive

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

for
Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma,
Location: Seattle WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 1 - 26

Code: NCT04185038

Phase1, Recruiting
Active & Responsive

Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

for
Glioblastoma (GBM), High Grade Gliomas, Recurrent Glioblastoma,
Location: Columbus OH
Sponsor: Trogenix ltd

Sex: All

Age: 18 - 70

Code: NCT07346144

Phase1, Phase2, Recruiting
Active & Responsive

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

for
AML (Acute Myeloid Leukemia), Glioma, Cholangiocarcinoma,
Location: New York NY, Orange CA
Sponsor: Rigel Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07486713

Recruiting
Active & Responsive

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for
Glioblastoma (GBM), Newly Diagnosed Glioblastoma, GBM,
Location: Boston MA, New Haven CT, Lake Success NY, The Bronx NY,
Sponsor: Black Diamond Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07326566

Phase2, Recruiting
Active & Responsive

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for
Glioma, Astrocytoma, Grade IV, IDH1-mutant Glioma,
Location: Boston MA, New Haven CT, New York NY, New Brunswick NJ,
Sponsor: Nuvation Bio Inc.

Sex: All

Age: 18+

Code: NCT05303519

Phase3, Recruiting
Active & Responsive

Super-Selective Intraarterial Intracranial Infusion of Bevacizumab (Avastin) for Glioblastoma Multiforme

for
Glioblastoma Multiforme
Location: Philadelphia PA
Sponsor: Global Neurosciences Institute

Sex: All

Age: 18+

Code: NCT02285959

Phase1, Recruiting
Active & Responsive

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

for
Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary,
Location: Boston MA, Providence RI, Valhalla NY, The Bronx NY,
Sponsor: GT Medical Technologies, Inc.

Sex: All

Age: 0+

Code: NCT04427384

Recruiting
Active & Responsive

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for
Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver,
Location: Scarborough ME, Worcester MA, Hartford CT, Norwalk CT,
Sponsor: Massive Bio, Inc.

Sex: All

Age: 0+

Code: NCT03452774

Recruiting
Active & ResponsiveNew

Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation

for
Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation,
Location: Boston MA, Chicago IL, Minneapolis MN, Los Angeles CA
Sponsor: Institut de Recherches Internationales Servier (I.R.I.S.)

Sex: All

Age: 12 - 17

Code: NCT07286292

Phase2, Recruiting
Active & ResponsiveNew

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

for
Newly Diagnosed Glioblastoma, Recurrent Glioblastoma
Location: Durham NC
Sponsor: Mustafa Khasraw, MBChB, MD, FRCP, FRACP

Sex: All

Age: 18+

Code: NCT04903795

Phase1, Recruiting
Active & Responsive

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

for
Glioblastoma, IDH-Wildtype
Location: Durham NC, Winston-Salem NC, Morgantown WV,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT06319027

Phase2, Recruiting
Active & Responsive

A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy

for
Phase 1b, Open Label, REC-617, RB1-Negative, Leiomyosarcoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07633756

Phase1, Recruiting
Active & Responsive

Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)

for
Glioblastoma Multiforme (GBM),
Location: Houston TX
Sponsor: Radiomedix, Inc.

Sex: All

Age: 18+

Code: NCT07733674

Phase1, Recruiting