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Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

for
High Grade Glioma, Glioblastoma
Location: Cleveland OH
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05565118

Phase1, Recruiting

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

for
Glioma, Glioma, Malignant, Glioblastoma,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT05979064

Recruiting

Targeted Pediatric High-Grade Glioma Therapy

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma,
Location: Washington D.C. DC, Durham NC, Miami FL, Columbus OH,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 1 - 39

Code: NCT05839379

Recruiting

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

for
Recurrent High Grade Glioma, Anaplastic Astrocytoma,
Location: Omaha NE
Sponsor: University of Nebraska

Sex: All

Age: 19+

Code: NCT05698524

Phase1, Recruiting

18F-Fluciclovine PET-MRI in High-grade Glioma

for
Glioma, High Grade Glioma, Glioma, Malignant,
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 1 - 21

Code: NCT05553041

Early_phase1, Recruiting

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DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

for
High Grade Glioma, MGMT-Unmethylated Glioblastoma,
Location: Lake Success NY, Miami FL, San Diego CA, Los Angeles CA,
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06504381

Phase1, Phase2, Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma,
Location: Washington D.C. DC, Durham NC, Miami FL, Columbus OH,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 3 - 39

Code: NCT05096481

Phase2, Recruiting

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

for
Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT05954858

Recruiting

MRI in High-Grade Glioma Patients Undergoing Chemoradiation

for
High Grade Glioma
Location: Winston-Salem NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT05212272

Recruiting

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

for
Glioma, Low-grade Glioma, Low Grade Glioma of Brain,
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 1 - 21

Code: NCT05555550

Early_phase1, Recruiting

A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions

for
High Grade Glioma, Glioblastoma
Location: Chandler AZ, Phoenix AZ
Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All

Age: 18+

Code: NCT06072586

Early_phase1, Recruiting

Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors

for
High-grade Glioma, Solid Tumor, Unspecified, Child
Location: Edison NJ, Miami FL, Little Rock AR
Sponsor: Laminar Pharmaceuticals

Sex: All

Age: 0 - 18

Code: NCT04299191

Phase1, Phase2, Recruiting

Window of Opportunity Study of DSP-0390 in Gliomas

for
Glioma, Malignant, IDH Mutation
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06636162

Early_phase1, Recruiting

Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma

for
High Grade Glioma
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 10 - 70+

Code: NCT05632562

Early_phase1, Recruiting

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

for
High Grade Glioma, CNS Tumor
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 3

Code: NCT06528691

Phase2, Recruiting

Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252

for
Recurrent High Grade Glioma
Location: New York NY, Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT06126744

Phase1, Recruiting

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

for
Glioblastoma, Glioblastoma Multiforme, Glioma, Malignant, GBM,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT05271240

Phase3, Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma
Location: Boston MA, Montreal, Philadelphia PA,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 0 - 21

Code: NCT04655404

Early_phase1, Recruiting

Study of Olutasidenib and Temozolomide in HGG

for
High Grade Glioma, Astrocytoma, Astrocytoma, Grade III,
Location: Durham NC, Miami FL, Columbus OH, Cincinnati OH,
Sponsor: Rigel Pharmaceuticals

Sex: All

Age: 12 - 39

Code: NCT06161974

Phase2, Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma,
Location: Columbus OH, Cincinnati OH
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 1 - 21

Code: NCT06333899

Early_phase1, Recruiting