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Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

for
High-grade Glioma, WHO Grade Ⅳ Glioma
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Tcelltech Inc.

Sex: All

Age: 18 - 70+

Code: NCT06482905

Phase1, Recruiting

Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas

for
High-Grade Glioma
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT06829173

Early_phase1, Recruiting

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

for
Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG,
Location: Washington D.C. DC, Toronto, Columbus OH, Ann Arbor MI,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 1 - 39

Code: NCT06838676

Phase2, Recruiting

CUE-102 in Recurrent Glioblastoma

for
Recurrent Glioblastoma, Glioblastoma, Glioma, Malignant
Location: Boston MA
Sponsor: David Reardon, MD

Sex: All

Age: 18+

Code: NCT06917885

Phase1, Recruiting

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

for
Glioma, Glioma, Malignant, Recurrent Glioma
Location: Miami FL
Sponsor: Baptist Health South Florida

Sex: All

Age: 18+

Code: NCT06397560

Recruiting

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C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

for
Diffuse Intrinsic Pontine Glioma, High Grade Glioma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 1 - 25

Code: NCT04099797

Phase1, Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for
High Grade Glioma, Diffuse Intrinsic Pontine Glioma,
Location: Washington D.C. DC, Durham NC, Columbus OH,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 1 - 39

Code: NCT05843253

Phase2, Recruiting

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

for
High-grade Glioma, Medulloblastoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 2 - 25

Code: NCT06624371

Phase1, Recruiting

Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors

for
Malignant Brain Glioma
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 0 - 21

Code: NCT04908709

Recruiting

Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial

for
Low Grade Glioma, Malignant Brain Glioma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06132685

Phase2, Recruiting

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

for
Low Grade Glioma, High Grade Glioma
Location: Chicago IL
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All

Age: 1 - 26

Code: NCT06712875

Phase1, Phase2, Recruiting

A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)

for
High Grade Glioma, Replication Repair Deficient
Location: Toronto
Sponsor: Daniel Morgenstern

Sex: All

Age: 1 - 25

Code: NCT06519682

Recruiting

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

for
Brain Tumor, Cancer
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 15+

Code: NCT05588141

Phase1, Phase2, Recruiting

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for
Non Small Cell Lung Cancer, Glioma Glioblastoma Multiforme,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Tango Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06810544

Phase1, Phase2, Recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for
Recurrent Glioblastoma,
Location: Bethesda MD
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All

Age: 18 - 70+

Code: NCT07416188

Phase1, Phase2, Recruiting

Imaging of Solid Tumors Using 18F-TRX

for
Solid Tumor, Solid Carcinoma,
Location: San Francisco CA
Sponsor: Rahul Aggarwal

Sex: All

Age: 18+

Code: NCT06942104

Phase1, Recruiting

A Phase II Study Of Gliadel, Concomitant Temozolomide And Radiation, Followed By Dose Dense Therapy With Temozolomide Plus Bevacizumab For Newly Diagnosed Malignant High Grade Glioma

for
Glioma
Location: Louisville KY
Sponsor: Kentuckiana Cancer Institute

Sex: All

Age: 18 - 70+

Code: NCT00660621

Phase2, Recruiting

Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions

for
Glioma, Glioblastoma,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT04047264

Recruiting

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

for
Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype,
Location: Boston MA, Boynton Beach FL, Nashville TN, Dallas TX,
Sponsor: Neonc Technologies, Inc.

Sex: All

Age: 18+

Code: NCT06047379

Phase1, Phase2, Recruiting

NeuroPathways Intervention for Brain Tumor Patients

for
Malignant Brain Tumor, Glioma, Coping Skills
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT05976490

Recruiting