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Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

for
Recurrent World Health Organization (WHO) Grade II Glioma,
Location: New York NY, Hackensack NJ, Philadelphia PA,
Sponsor: University of California, San Francisco

Sex: All

Age: 1 - 25

Code: NCT04485559

Phase1, Recruiting

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

for
Astrocytoma, IDH-Mutant, Grade 2,
Location: New Haven CT, Trumbull CT, Mineola NY, New York NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06860594

Phase1, Recruiting

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for
Adenocarcinoma, Basal Cell Carcinoma, Squamous Cell Carcinoma,
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT07628634

Early_phase1, Recruiting

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

for
Brain Cancer, HGG, Glioma, High Grade Glioma,
Location: Nashville TN
Sponsor: Eben Rosenthal

Sex: All

Age: 18+

Code: NCT07210632

Early_phase1, Recruiting

A Study of Mirdametinib in People With Central Nervous System Tumors

for
Central Nervous System Tumors, Glioma
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07539441

Phase1, Phase2, Recruiting

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A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.

for
CNS Malignancies, Medulloblastoma Recurrent, ATRT Recurrent,
Location: Washington D.C. DC
Sponsor: Children's National Research Institute

Sex: All

Age: 3 - 21

Code: NCT07017816

Early_phase1, Recruiting

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

for
Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant,
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 3 - 39

Code: NCT06914479

Phase1, Recruiting

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

for
Recurrent CNS Tumors, Brain Cancer, Gliomas,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 15 - 70+

Code: NCT07374692

Recruiting

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

for
Recurrent Glioblastoma, Recurrent Gliomas
Location: New York NY, Columbus OH, Scottsdale AZ
Sponsor: Alpha Tau Medical LTD.

Sex: All

Age: 18 - 70+

Code: NCT06910306

Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for
Diffuse Midline Glioma, H3 K27-Altered,
Location: Boston MA, Valhalla NY, New York NY, Philadelphia PA,
Sponsor: Children's Oncology Group

Sex: All

Age: 1 - 21

Code: NCT04870944

Phase1, Phase2, Recruiting

A Study of 177Lu-PSMA-617 in People With Gliomas

for
Glioma, Diffuse Astrocytoma, IDH-Wildtype (Grade 2-4),
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07223034

Phase1, Recruiting

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

for
Atypical Teratoid/Rhabdoid Tumor,
Location: Hartford CT, Hackensack NJ, Hershey PA, Miami FL,
Sponsor: Milton S. Hershey Medical Center

Sex: All

Age: 0 - 26

Code: NCT06465199

Phase1, Phase2, Recruiting

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

for
Brain Cancer, Brain Tumor, Brain Neoplasms, Primary Brain Tumor,
Location: Lebanon NH
Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All

Age: 18+

Code: NCT06930846

Recruiting

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial

for
Glioma, Recurrent Glioma, Recurrent Glioblastoma
Location: Jacksonville FL, Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07074756

Recruiting

Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

for
GBM, Glioblastoma Multiforme (GBM),
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18 - 70+

Code: NCT07179328

Phase1, Recruiting

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

for
Glioblastoma, IDH-Wildtype, WHO Grade 4 Glioma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT07091864

Recruiting

Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma

for
Recurrent Glioblastoma, IDH-Wildtype,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT06410248

Phase1, Recruiting

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

for
Glioblastoma Multiforme of Brain, Glioma, Glioblastoma
Location: New York NY, Tampa FL, Chicago IL
Sponsor: Tetragon Biosciences Ltd

Sex: All

Age: 18+

Code: NCT07464925

Phase1, Recruiting

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

for
Medulloblastoma, Medulloblastoma, Childhood,
Location: New York NY, Philadelphia PA, Washington D.C. DC,
Sponsor: University of California, San Francisco

Sex: All

Age: 1 - 39

Code: NCT05057702

Recruiting

FearLess in NeuroOncology

for
Primary Malignant Brain Tumor, Glioblastoma (GBM), Astrocytoma,
Location: Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06989086

Recruiting