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Familial Investigations of Childhood Cancer Predisposition

for
Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0+

Code: NCT03050268

Recruiting

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

for
Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05039801

Phase1, Recruiting

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

for
Metastatic Melanoma, Unresectable Melanoma, Melanoma
Location: Lebanon NH, Montreal, Camden NJ, Bethesda MD, Toronto,
Sponsor: Iovance Biotherapeutics, Inc.

Sex: All

Age: 18 - 70

Code: NCT05727904

Phase3, Recruiting

Pan-tumor MRD Study

for
Muscle Invasive Bladder Urothelial Carcinoma, Esophageal Cancer,
Location: Maumee OH, San Diego CA
Sponsor: Flatiron Health

Sex: All

Age: 18+

Code: NCT06605404

Recruiting

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT05098210

Phase1, Recruiting

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for
Recurrent Melanoma (Skin), Metastatic Melanoma,
Location: Philadelphia PA, Miami FL, Pittsburgh PA,
Sponsor: Perspective Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT05655312

Phase1, Phase2, Recruiting

LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study

for
Cancer, Tyrosine Kinase Mutation, Breast Cancer, Melanoma,
Location: Edmonton
Sponsor: University of Alberta

Sex: All

Age: 18 - 70+

Code: NCT05645510

Recruiting

Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma

for
Uveal Melanoma
Location: Washington D.C. DC, Pittsburgh PA, Columbus OH,
Sponsor: Diwakar Davar

Sex: All

Age: 18+

Code: NCT06070012

Phase2, Recruiting

High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies

for
Liver Malignant Tumors, Cholangiocarcinoma Metastatic,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 19+

Code: NCT05053555

Recruiting

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

for
Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma,
Location: Morristown NJ, Miami FL, Huntersville NC,
Sponsor: Aulos Bioscience, Inc.

Sex: All

Age: 18+

Code: NCT05267626

Phase1, Phase2, Recruiting

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

for
Melanoma Stage IV, Solid Tumor
Location: Boston MA, New York NY, Richmond VA, Cincinnati OH,
Sponsor: Georgiamune Inc

Sex: All

Age: 18+

Code: NCT06425926

Phase1, Phase2, Recruiting

Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)

for
Melanoma (Skin Cancer), Breast Cancer, Brain Metastasases
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06545682

Phase1, Recruiting

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04771520

Phase2, Recruiting

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

for
Melanoma Stage IIIB, Melanoma Stage IIIC, Melanoma Stage IIID
Location: Ney York NY, New Brunswick NJ, Philadelphia PA,
Sponsor: Philogen S.p.A.

Sex: All

Age: 18+

Code: NCT03567889

Phase3, Recruiting

A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma

for
Advanced Melanoma
Location: Hartford CT, Commack NY, Uniondale NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06594991

Phase2, Recruiting

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

for
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC),
Location: North Haven CT, Lake Success NY, Chapel Hill NC,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06413680

Phase1, Phase2, Recruiting

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

for
Cutaneous Melanoma, Brain Metastases
Location: Iowa City IA, Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18+

Code: NCT06194929

Phase1, Phase2, Recruiting

A Beta-only IL-2 ImmunoTherapY Study

for
Advanced Solid Tumor, Unresectable Solid Tumor,
Location: Boca Raton FL, Toronto, Detroit MI, Atlanta GA,
Sponsor: Medicenna Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05086692

Phase1, Phase2, Recruiting

Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes

for
Melanoma
Location: Maywood IL
Sponsor: Loyola University

Sex: All

Age: 18 - 70+

Code: NCT02870244

Phase1, Recruiting

Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma

for
Melanoma, Melanoma Stage III, Melanoma (Skin),
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT06771544

Phase2, Recruiting