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Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

for
Refractory Metastatic Colorectal Cancer
Location: Tampa FL, New Orleans LA, Fairway KS, Salt Lake City UT,
Sponsor: Delcath Systems Inc.

Sex: All

Age: 18+

Code: NCT06607458

Phase2, Recruiting

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

for
Metastatic Colorectal Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06959550

Phase2, Recruiting

Trial of ProAgio in Advanced/Metastatic Colorectal Cancer

for
Advanced Colorectal Cancer, Metastatic Colorectal Cancer
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 19+

Code: NCT06867822

Phase1, Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

for
Metastatic Colorectal Cancer
Location: New Haven CT, Cleveland OH, Grand Rapids MI, Houston TX
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT07079631

Phase1, Phase2, Recruiting

5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer

for
Metastatic Colorectal Cancer (CRC)
Location: Houston TX
Sponsor: The Methodist Hospital Research Institute

Sex: All

Age: 18+

Code: NCT06887218

Phase2, Recruiting

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Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

for
Colorectal Cancer, Metastatic Colon Cancer,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18 - 50

Code: NCT06202183

Recruiting

Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy

for
Metastatic Colorectal Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05985954

Phase1, Recruiting

A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations

for
Metastatic Colorectal Cancer, KRAS G12C Mutations
Location: Boston MA, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06412198

Phase1, Phase2, Recruiting

Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis

for
Metastatic Colorectal Cancer
Location: Montreal
Sponsor: Alethia Biotherapeutics

Sex: All

Age: 18+

Code: NCT06225843

Phase2, Recruiting

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

for
Metastatic Colorectal Cancer
Location: Durham NC, Toronto, Brampton, Jacksonville FL,
Sponsor: Amgen

Sex: All

Age: 18+

Code: NCT06252649

Phase3, Recruiting

Conversion From Unresectable To Resectable Metastatic Colorectal Cancer.

for
Metastatic Colorectal Cancer
Location: Regina
Sponsor: University of Saskatchewan

Sex: All

Age: 18 - 70

Code: NCT03401294

Phase2, Recruiting

Dabrafenib + Trametinib + PDR001 In Colorectal Cancer

for
Metastatic Colorectal Cancer
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT03668431

Phase2, Recruiting

Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC)

for
Peritoneal Carcinomatosis, Appendiceal Neoplasms,
Location: Montreal
Sponsor: Ciusss de L'Est de l'Île de Montréal

Sex: All

Age: 18+

Code: NCT05913674

Phase2, Recruiting

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

for
Colorectal Cancer Metastatic, Liver Metastases,
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 18+

Code: NCT06300463

Phase2, Recruiting

Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases

for
Colorectal Cancer Metastatic
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 18+

Code: NCT05248581

Recruiting

INFINITIVE: ImmuNotherapy For PatIeNts wIth colorecTal LIVer MEtastases

for
Colorectal Cancer Metastatic
Location: Lake Success NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT07172282

Early_phase1, Recruiting

Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy

for
Colorectal Cancer Metastatic, Intrahepatic Cholangiocarcinoma
Location: Lexington KY
Sponsor: Michael J Cavnar, MD

Sex: All

Age: 18 - 70+

Code: NCT07201519

Phase2, Recruiting

Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Colorectal Liver Metastasis

for
Colorectal Cancer Metastatic
Location: Lake Success NY, New Hyde Park NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT07193862

Early_phase1, Recruiting

Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer

for
Liver Metastasis Colon Cancer
Location: London
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All

Age: 18+

Code: NCT05314400

Recruiting

Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer

for
Metastatic Colorectal Adenocarcinoma,
Location: Fullerton CA, Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18+

Code: NCT06336902

Phase1, Recruiting