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Early Detection of Treatment Failure in Metastatic Colorectal Cancer Patients

for
Colorectal Cancer Metastatic
Location: Montreal
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All

Age: 18+

Code: NCT05068531

Recruiting

Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer

for
Advanced or Metastatic CRC
Location: Houston TX
Sponsor: The Methodist Hospital Research Institute

Sex: All

Age: 18+

Code: NCT06833866

Phase1, Recruiting

Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer

for
Colon Cancer, Rectal Cancer
Location: Long Branch NJ, Toms River NJ, Jersey City NJ,
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 18+

Code: NCT05806931

Phase2, Recruiting

Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer

for
Breast Carcinoma, Colorectal Carcinoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06130826

Phase1, Recruiting

A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer

for
Colorectal Cancer
Location: New Haven CT, New York NY, New Brunswick NJ,
Sponsor: Criterium, Inc.

Sex: All

Age: 18+

Code: NCT06992258

Phase2, Recruiting

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cfDNA 5mC/5hmC Biomarkers to Predict Chemotherapy Response in Metastatic Colorectal Cancer

for
CRC (Colorectal Cancer)
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07224815

Recruiting

Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer

for
Metastatic Colorectal Adenocarcinoma
Location: Port Huron MI, Macomb MI, Detroit MI, Lapeer MI,
Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All

Age: 22+

Code: NCT07130903

Phase2, Recruiting

A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation

for
Advanced/Metastatic Colorectal Adenocarcinoma
Location: Irving TX
Sponsor: Bayer

Sex: All

Age: 18+

Code: NCT07535112

Phase1, Recruiting

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)

for
Colon Cancer, Rectal Cancer, Colorectal Cancer,
Location: Wynnewood PA, Norfolk VA, Columbia MD, Salem VA,
Sponsor: SCRI Development Innovations, LLC

Sex: All

Age: 18+

Code: NCT07011576

Phase2, Recruiting

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

for
Colorectal Neoplasms
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT05253651

Phase3, Recruiting

Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

for
Metastatic Colorectal Adenocarcinoma,
Location: Gainesville FL, Nashville TN, Shiloh IL, St Louis MO,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06696768

Phase1, Recruiting

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

for
Metastatic Colorectal Adenocarcinoma,
Location: Boston MA, Lebanon NH, Commack NY, Greenlawn NY,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT05673148

Phase2, Recruiting

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

for
Metastatic Microsatellite Stable Colorectal Carcinoma,
Location: The Bronx NY, Pittsburgh PA, Cincinnati OH,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06654037

Phase1, Recruiting

In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung

for
Lung Metastases, Colorectal Cancer Metastatic,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18 - 70

Code: NCT05611034

Phase1, Recruiting

Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection

for
Liver Transplant Surgery, Colorectal Cancer Metastatic,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT06698146

Recruiting

Phase 2 Study of SR-8541A in Combination With Botensilimab and Balstilimab in Subjects With Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC)

for
Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC),
Location: Morristown NJ, Tyler TX, Houston TX, Dallas TX,
Sponsor: Stingray Therapeutics

Sex: All

Age: 18+

Code: NCT06589440

Phase2, Recruiting

Medical Cannabis in Patients With Advanced Pancreatic and Colorectal Cancer

for
Pancreatic Cancer Non-resectable, Pancreatic Cancer Metastatic,
Location: Saint Louis Park MN
Sponsor: HealthPartners Institute

Sex: All

Age: 18+

Code: NCT06605430

Phase2, Recruiting

Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC

for
Metastatic Microsatellite Stable Colorectal Carcinoma
Location: New York NY
Sponsor: Dan Feng

Sex: All

Age: 18+

Code: NCT07281716

Phase1, Phase2, Recruiting

A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

for
Colorectal Neoplasms, Gastrointestinal Neoplasms
Location: Sarasota FL, Grand Rapids MI, Indianapolis IN,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06663319

Phase1, Recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

for
Colorectal Neoplasms
Location: Shirley NY, New Haven CT, Mineola NY, The Bronx NY,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06662786

Phase3, Recruiting