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This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

for
Non Small Cell Lung Cancer,
Location: Boston MA, Austin, TX 78758 TX, San Antonio TX
Sponsor: Zumutor Biologics Inc.

Sex: All

Age: 18+

Code: NCT06451497

Phase1, Recruiting

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

for
Cancer, Advanced Cancer, Locally Advanced Carcinoma,
Location: Fairfax VA, Sarasota FL, Nashville TN, St Louis MO,
Sponsor: Angiex, Inc.

Sex: All

Age: 18+

Code: NCT06440005

Phase1, Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

for
Endometrial Cancer, Gastric Cancer,
Location: Commack NY, East Brunswick NJ, Columbus OH,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT05489211

Phase2, Recruiting

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

for
Stage IV Esophageal Adenocarcinoma,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT04221893

Recruiting

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

for
Breast Cancer, Gastric Cancer, Esophageal Cancer,
Location: New York NY, Nashville TN, Houston TX, Dallas TX,
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06695845

Phase2, Recruiting

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A Phase 1/1b Study of IAM1363 in HER2 Cancers

for
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer,
Location: Boston MA, Lebanon NH, New York NY, New Brunswick NJ,
Sponsor: Iambic Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06253871

Phase1, Recruiting

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for
Advanced Solid Tumors With KRAS G12C Mutations,
Location: Boston MA, Philadelphia PA, Fairfax VA, Detroit MI,
Sponsor: Frontier Medicines Corporation

Sex: All

Age: 18+

Code: NCT06244771

Phase1, Phase2, Recruiting

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

for
Metastatic Uveal Melanoma, Cutaneous Melanoma,
Location: Philadelphia PA, Durham NC, Cincinnati OH, Nashville TN,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18+

Code: NCT03947385

Phase1, Phase2, Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for
Advanced Solid Tumor, Advanced Malignant Neoplasm,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: PMV Pharmaceuticals, Inc

Sex: All

Age: 12+

Code: NCT04585750

Phase1, Phase2, Recruiting

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

for
Clinical Stage IV Gastric Cancer AJCC v8,
Location: Greenlawn NY, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT04329494

Phase1, Recruiting

A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

for
Colorectal Cancer, Liver Metastases
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06130280

Phase2, Recruiting

Liver Transplantation for Unresectable Liver Limited Colorectal Metastases

for
Unresectable Liver-limited Colorectal Metastases
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 18 - 65

Code: NCT04742621

Recruiting

A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

for
Appendiceal Cancer, Colorectal Adenocarcinoma,
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18 - 70+

Code: NCT07291180

Recruiting

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

for
Ewing Sarcoma, Colorectal Adenocarcinoma
Location: New York NY, Philadelphia PA, Fairfax VA,
Sponsor: Inhibrx Biosciences, Inc

Sex: All

Age: 12 - 70+

Code: NCT03715933

Phase1, Recruiting

Safety of HRX215 in Patients After Minor and Major Liver Resection

for
Liver Resection, Colorectal Carcinoma Liver Metastases
Location: Baltimore MD, Durham NC, Cleveland OH, Rochester MN
Sponsor: HepaRegeniX GmbH

Sex: All

Age: 18 - 70+

Code: NCT06638502

Phase1, Phase2, Recruiting

PET Imaging Using 64Cu-Tz-SarAr and hu5B1-TCO in People With Pancreatic, Colorectal, Bladder Cancer or Cancers With Elevated CA19.9

for
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma,
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05737615

Phase1, Recruiting

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

for
Cancer Pain, Visceral Pain, Gastrointestinal Neoplasms,
Location: Los Angeles CA
Sponsor: Cedars-Sinai Medical Center

Sex: All

Age: 18 - 70+

Code: NCT04907643

Recruiting

Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma

for
Gastric Cancer, Gastric Adenocarcinoma,
Location: Fairfax VA
Sponsor: BigHat Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT07529808

Phase1, Phase2, Recruiting
New

BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

for
Metastatic Biliary Tract Carcinoma, Metastatic Colon Carcinoma,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT07594626

Phase1, Phase2, Recruiting