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Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial

for
Locally Advanced Bladder Urothelial Carcinoma,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06764095

Recruiting

CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

for
Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT05733000

Phase2, Recruiting

A Study of Pembrolizumab+ sEphB4 in Metastatic Urothelial Carcinoma

for
Metastatic Urothelial Carcinoma
Location: Santa Monica CA
Sponsor: Vasgene Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT04486781

Phase2, Recruiting

A Study of NX-1607 in Adults With Advanced Malignancies

for
Ovarian Cancer, Epithelial, Gastric Cancer,
Location: Charlottesville VA, Chapel Hill NC, Chicago IL,
Sponsor: Nurix Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05107674

Phase1, Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 16+

Code: NCT05269381

Phase1, Phase2, Recruiting

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A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

for
Head and Neck Squamous Cell Carcinoma HNSCC,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Sutro Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07227168

Phase1, Recruiting

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

for
Urothelial Cancer, Bladder Cancer
Location: Norfolk VA, Chapel Hill NC, Grand Rapids MI,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT07129993

Phase2, Phase3, Recruiting

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

for
Solid Tumor Cancer, Locally Advanced, Metastatic Solid Tumors,
Location: Washington D.C. DC, Sarasota FL, Atlanta GA, Houston TX,
Sponsor: Avenzo Therapeutics, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07038343

Phase1, Phase2, Recruiting

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

for
Castration-Resistant Prostate Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04693377

Recruiting

Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors

for
Muscle-Invasive Bladder Carcinoma,
Location: Santa Monica CA
Sponsor: Vasgene Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06493552

Phase2, Phase3, Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

for
Endometrial Cancer, Gastric Cancer,
Location: Commack NY, East Brunswick NJ, Columbus OH,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT05489211

Phase2, Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for
Urothelial Carcinoma Bladder,
Location: New York NY, Glen Burnie MD, Miami FL, Pittsburgh PA,
Sponsor: Aktis Oncology, Inc.

Sex: All

Age: 18+

Code: NCT07020117

Phase1, Recruiting

Gemcitabine and Carboplatin After Progression on Enfortumab Vedotin and Pembrolizumab in Advanced/Metastatic Urothelial Carcinoma

for
Urothelial Carcinoma
Location: Philadelphia PA
Sponsor: Fox Chase Cancer Center

Sex: All

Age: 18+

Code: NCT07043972

Phase2, Recruiting

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

for
Early Stage Triple-Negative Breast Carcinoma,
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06349642

Recruiting

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

for
Bladder Adenocarcinoma, Bladder Clear Cell Adenocarcinoma,
Location: Peabody MA, Burlington MA, Commack NY, Uniondale NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT03866382

Phase2, Recruiting

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

for
Cervical Cancer,
Location: Hackensack NJ, Montreal, Hamilton, Nashville TN,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT04895709

Phase1, Phase2, Recruiting

A Study of VET3-TGI in Patients With Solid Tumors

for
Solid Tumor, Adult, Microsatellite Stable Colorectal Cancer,
Location: Miami FL, Pittsburgh PA, Indianapolis IN, Houston TX,
Sponsor: KaliVir Immunotherapeutics

Sex: All

Age: 18+

Code: NCT06444815

Phase1, Recruiting

Neoadjuvant PD-1 Plus TIGIT Blockade in Patients With Cisplatin-Ineligible Operable High-Risk Urothelial Carcinoma

for
Metastatic Malignancy
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05394337

Phase1, Phase2, Recruiting

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

for
Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype,
Location: Boston MA, Boynton Beach FL, Nashville TN, Dallas TX,
Sponsor: Neonc Technologies, Inc.

Sex: All

Age: 18+

Code: NCT06047379

Phase1, Phase2, Recruiting