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A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications

for
Acute Myeloid Leukemia/Myelodysplastic Syndrome,
Location: Buffalo NY, Tampa FL
Sponsor: Celyad Oncology SA

Sex: All

Age: 18+

Code: NCT03018405

Phase1, Phase2, Recruiting

A Study of APG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDS

for
AML, Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia,
Location: Fairfax VA, Durham NC, Tyler TX, Houston TX, Dallas TX,
Sponsor: Ascentage Pharma Group Inc.

Sex: All

Age: 18+

Code: NCT04358393

Phase1, Phase2, Recruiting

Antiminor Histocompatibility Complex (MiHA) T Cells for Patients With Relapsed Hematologic Malignancies Following Matched HSCT (Guided Lymphocyte Immunopeptide Derived Expansion)

for
Hematologic Cancer, Relapse Leukemia, Relapsed Adult ALL,
Location: Montreal
Sponsor: Ciusss de L'Est de l'Île de Montréal

Sex: All

Age: 18 - 65

Code: NCT03091933

Phase1, Phase2, Recruiting

Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

for
Acute Bilineal Leukemia, Acute Biphenotypic Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03683433

Phase2, Recruiting

Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

for
Severe Aplastic Anemia (SAA),
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 4 - 70+

Code: NCT03520647

Phase2, Recruiting

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Methylprednisolone, Horse Anti-Thymocyte Globulin, Cyclosporine, Filgrastim, and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic Syndrome

for
Aplastic Anemia, de Novo Myelodysplastic Syndrome,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT01624805

Phase2, Recruiting

HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML

for
Myeloid Malignancy, Acute Myeloid Leukemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18+

Code: NCT06594445

Phase1, Recruiting

Mosaic Trial for Stem Cell Transplant Recipients

for
Hematologic Malignancy, Stem Cell Transplant,
Location: Nutley NJ, Washington D.C. DC, Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT06960993

Recruiting

Clinical Study of ARD103 CAR-T Therapy for Patients With R/R AML or MDS

for
Acute Myeloid Leukemia, in Relapse,
Location: Winston-Salem NC, Charlotte NC, Houston TX
Sponsor: ARCE Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06680752

Phase1, Phase2, Recruiting

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

for
Fanconi Anemia, Severe Aplastic Anemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 65

Code: NCT03579875

Phase2, Recruiting

Personalized NK Cell Therapy in CBT

for
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 15 - 70+

Code: NCT02727803

Phase2, Recruiting

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for
Acute Myeloid Leukemia,
Location: Halifax, Brunswick ME, Portland ME, Scarborough ME,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05564390

Phase2, Recruiting

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Halifax, Bangor ME, Scarborough ME, Boston MA,
Sponsor: PedAL BCU, LLC

Sex: All

Age: 0 - 22

Code: NCT04726241

Phase1, Phase2, Recruiting

Defining Inflammatory Markers of Cardiovascular Disease in Patients With Myelodysplastic Syndromes

for
Myelodysplastic Syndromes, Adult
Location: Burlington VT
Sponsor: University of Vermont

Sex: All

Age: 18+

Code: NCT06692894

Recruiting

Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia

for
Myelodysplastic Syndromes, Acute Myeloid Leukemia,
Location: Winnipeg
Sponsor: University of Manitoba

Sex: All

Age: 18+

Code: NCT06599762

Phase2, Recruiting

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

for
Myelodysplastic Syndromes,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05365035

Phase2, Recruiting

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Boston MA, New Haven CT, Commack NY, Uniondale NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06484062

Phase1, Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia in Remission,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT03670966

Phase1, Phase2, Recruiting

Tacrolimus and MMF as Post Grafting Immunosuppression After Conditioning With Flu TBI for HLA Matched Family Donor

for
Multiple Myeloma, Lymphoma, Acute Myelogenous Leukemia,
Location: Denver CO
Sponsor: Colorado Blood Cancer Institute

Sex: All

Age: 50 - 70

Code: NCT00304720

Phase2, Recruiting
New

Post-Marketing Study for Early-Stage Low-Risk Breast Cancer Treatment Using ProSense® Cryoablation (ChoICE Trial)

for
Low-Risk, Early Stage Breast Cancer
Location: Germantown TN, Glendale CA
Sponsor: IceCure Medical Ltd.

Sex: All

Age: 70+

Code: NCT07629206

Recruiting