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A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

for
Accelerated Phase Myeloproliferative Neoplasm,
Location: New York NY, Richmond VA, North Miami FL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06661915

Phase2, Recruiting

Caris Chromoseq Data Collection

for
Acute Myeloid Leukemia (AML),
Location: Phoenix AZ
Sponsor: Caris Science, Inc.

Sex: All

Age: 18+

Code: NCT07680868

Recruiting

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

for
Malignancy, Hematologic, Neoplasms, Hematologic,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06904066

Phase1, Recruiting

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for
Hematologic Malignancies, Inherited Disorders of Metabolism,
Location: Boston MA, New Haven CT, Stony Brook NY, Lake Sucess NY,
Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All

Age: 0+

Code: NCT01351545

Recruiting

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

for
Acute Myeloid Leukemia,
Location: Halifax, Portland ME, Scarborough ME, South Portland ME,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 59

Code: NCT05554406

Phase2, Recruiting

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Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

for
Recurrent Endometrial Carcinoma,
Location: Providence RI, Philadelphia PA, Cleveland OH,
Sponsor: National Cancer Institute (NCI)

Sex: Female

Age: 18+

Code: NCT05950464

Phase1, Recruiting

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for
Non-small Cell Lung Cancer,
Location: Boston MA, New York NY, New Brunswick NJ, Pittsburgh PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05877599

Phase1, Recruiting

Stem Cell Ophthalmology Treatment Study II

for
Retinal Disease, Age-Related Macular Degeneration,
Location: Westport CT, Coral Springs FL
Sponsor: MD Stem Cells

Sex: All

Age: 18+

Code: NCT03011541

Recruiting

Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

for
Hypertension, Overweight, Obesity, Cardiovascular Diseases,
Location: Miami FL
Sponsor: Duke University

Sex: All

Age: 50 - 70+

Code: NCT06604650

Recruiting

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

for
Breast Cancer, Metastatic Breast Cancer, Advanced Breast Cancer,
Location: Miami FL, Atlanta GA, Fairway KS
Sponsor: Reshma L. Mahtani, D.O.

Sex: All

Age: 18+

Code: NCT06263543

Phase2, Recruiting

MRI Guided Focal Laser Ablation of Prostate Cancer

for
Prostate Cancer, Low and Intermediate Risk Prostate Cancer
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: Male

Age: 40 - 70+

Code: NCT03650595

Recruiting

PRE-ISPY Phase I/II Oncology Platform Program

for
HER2-positive Breast Cancer, Metastatic Cancer,
Location: Birmingham AL, Chicago IL, Orland Park IL, New Lenox IL,
Sponsor: QuantumLeap Healthcare Collaborative

Sex: All

Age: 18+

Code: NCT05868226

Phase1, Phase2, Recruiting

CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies

for
Hematologic Malignancy, ALL, Childhood, AML, Childhood,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT06326463

Phase1, Recruiting

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for
Adipocytic Neoplasm, Liposarcoma, Atypical Fibroxanthoma,
Location: Boston MA, Atlanta GA, Cincinnati OH, Chicago IL,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 30

Code: NCT06239272

Phase1, Phase2, Recruiting

Micro-ultrasound-Guided Focal Laser Ablation for Intermediate-Risk Prostate Cancer: Safety & Effectiveness

for
Prostate Cancer (Adenocarcinoma),
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: Male

Age: 40 - 70+

Code: NCT07339943

Recruiting

TRUDI: TDXD+Durva in HER2+/Low IBC

for
Invasive Breast Cancer, Inflammatory Breast Cancer Stage III,
Location: Boston MA, Houston TX
Sponsor: Filipa Lynce, MD

Sex: Female

Age: 18+

Code: NCT05795101

Phase2, Recruiting

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for
Breast Cancer, HER2-low Breast Cancer, Metastatic Breast Cancer,
Location: Boston MA, New Haven CT, The Bronx NY,
Sponsor: Ana C Garrido-Castro, MD

Sex: All

Age: 18+

Code: NCT06533826

Phase2, Recruiting

Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers

for
Metastatic Breast Cancer, Triple Negative Breast Cancer,
Location: Durham NC, Buffalo NY, Atlanta GA, Lexington KY,
Sponsor: Kathy Miller

Sex: All

Age: 18+

Code: NCT05846789

Phase2, Recruiting

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

for
Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer,
Location: Boston MA, New York NY, Richmond VA, Columbus OH,
Sponsor: Regeneron Pharmaceuticals

Sex: Female

Age: 18+

Code: NCT03564340

Phase1, Phase2, Recruiting

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

for
Radiculopathy, Lumbosacral Region, Back Pain With Radiation,
Location: The Bronx NY
Sponsor: Montefiore Medical Center

Sex: All

Age: 18 - 70

Code: NCT05721027

Recruiting