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Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

for
Advanced or Metastatic KRAS-mutant Tumor in Pancreatic Adenocarcinoma,
Location: Toronto, Dallas TX, San Antonio TX
Sponsor: Auricula Biosciences Inc.

Sex: All

Age: 18+

Code: NCT07148128

Phase1, Phase2, Recruiting

NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial

for
Borderline Resectable Pancreatic Ductal Adenocarcinoma
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT06821997

Phase2, Recruiting

NLit and Outcomes in HNC Survivor-Caregiver Dyads

for
Head and Neck Cancer, Caregiver Burden,
Location: Kansas City KS
Sponsor: University of Kansas Medical Center

Sex: All

Age: 18+

Code: NCT07021885

Recruiting

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

for
Squamous Cell Carcinoma of Head and Neck, Sinus Cancer,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07063212

Phase2, Recruiting

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

for
Mesothelioma, Neoplasms, Stomach Neoplasms,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06885697

Phase1, Recruiting

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Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

for
Locally Advanced Pancreatic Adenocarcinoma
Location: Boston MA, Providence RI, Philadelphia PA,
Sponsor: EXACT Therapeutics AS

Sex: All

Age: 18+

Code: NCT06850623

Phase2, Recruiting

Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers

for
Head and Neck Carcinoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06985784

Recruiting

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for
Pancreatic Neuroendocrine Tumor (pNET),
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT06943755

Phase2, Phase3, Recruiting

Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula

for
Pancreatic Carcinoma, Pancreatic Neoplasm
Location: Easton PA, Quakertown PA, Stroudsburg PA, Bethlehem PA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT06807437

Phase3, Recruiting

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

for
Pancreatic Ductal Adenocarcinoma, Non Small Cell Lung Cancer,
Location: Boston MA, New York NY, Philadelphia PA, Baltimore MD,
Sponsor: Verastem, Inc.

Sex: All

Age: 18+

Code: NCT07020221

Phase1, Phase2, Recruiting

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

for
Head and Neck Squamous Cell Carcinoma,
Location: Shreveport LA
Sponsor: Pure Biologics S.A.

Sex: All

Age: 18+

Code: NCT06700070

Early_phase1, Recruiting

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for
Head and Neck Squamous Cell Carcinoma,
Location: Damariscotta ME, Bath ME, Augusta ME, Brunswick ME,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT06992427

Phase3, Recruiting

Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer

for
Head and Neck Cancer, Head and Neck Small Cell Carcinoma,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT07501650

Phase1, Recruiting

ONT01 and Gemcitabine/Nab-paclitaxel as Second Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma

for
Metastatic Pancreatic Ductal Adenocarcinoma
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06904378

Phase1, Phase2, Recruiting

Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

for
Head and Neck Squamous Cell Carcinoma (HNSCC),
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT07465276

Phase2, Recruiting

AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors

for
Vulvar Adenocarcinoma, PDAC - Pancreatic Ductal Adenocarcinoma,
Location: Fairfax VA, Grand Rapids MI, Irving TX
Sponsor: Avacta Life Sciences Ltd

Sex: All

Age: 18+

Code: NCT07454642

Phase1, Recruiting

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

for
Metastatic Head-and-neck Squamous-cell Carcinoma,
Location: South Portland ME, Boston MA, New Haven CT,
Sponsor: AVEO Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT06064877

Phase3, Recruiting

Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions

for
Pancreatic Cyst
Location: Boston MA, New Haven CT, Garden City NY, New York NY,
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT03492151

Recruiting

Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma

for
Squamous Cell Carcinoma of Head and Neck,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06606028

Recruiting

Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms

for
Pancreatic Cyst
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06305728

Recruiting