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CD4CAR for CD4+ Leukemia and Lymphoma

for
T-cell Lymphoma, T-cell Leukemia
Location: New York NY, Miami FL, Indianapolis IN, Houston TX
Sponsor: Huda Salman

Sex: All

Age: 12+

Code: NCT03829540

Phase1, Recruiting

Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab

for
Relapsed/Refractory, B-cell Acute Lymphocytic Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06287229

Phase1, Phase2, Recruiting

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

for
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC),
Location: North Haven CT, Lake Success NY, Chapel Hill NC,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06413680

Phase1, Phase2, Recruiting

Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer

for
Malignant Neoplasms of Respiratory and Intrathoracic Organs,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03114462

Phase1, Recruiting

Clinicopathologic and Ancillary Testing of Primary Clear Cell Carcinoma of the Cervix

for
Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: Female

Age: 0+

Code: NCT05046080

Recruiting

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A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab

for
B-Cell ALL, B-Cell Acute Lymphoblastic Leukaemia,
Location: Little Rock AR, Springdale AR
Sponsor: Arkansas Children's Hospital Research Institute

Sex: All

Age: 1 - 23

Code: NCT07422337

Recruiting

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

for
Refractory Non-Hodgkin Lymphoma, Burkitt Lymphoma,
Location: San Francisco CA
Sponsor: C. Babis Andreadis

Sex: All

Age: 18+

Code: NCT04545762

Phase1, Recruiting

Safety and Efficacy of Targeting PP2A in Ovarian Clear Cell Carcinoma Using Dostarlimab and LB-100

for
Ovarian Clear Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06065462

Phase1, Phase2, Recruiting

Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma

for
Diffuse Large B-Cell Lymphoma, High Grade B-Cell Lymphoma
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18 - 70+

Code: NCT06249191

Phase1, Phase2, Recruiting

The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial)

for
HPV-positive Oropharyngeal Squamous Cell Carcinoma
Location: New York NY, Paramus NJ
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT05419089

Phase2, Recruiting

Tislelizumab Consolidation After Liver-Directed Therapy for Hepatocellular Carcinoma

for
Carcinoma, Hepatocellular, Liver Cell Carcinoma
Location: The Bronx NY, New Brunswick NJ
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 18+

Code: NCT05366829

Phase2, Recruiting

UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL

for
B-cell Acute Lymphoblastic Leukemia,
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 0 - 30

Code: NCT04544592

Phase1, Phase2, Recruiting

Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy

for
Carcinoma, Non-Small-Cell Lung
Location: Hackensack NJ
Sponsor: Hackensack Meridian Health

Sex: All

Age: 18+

Code: NCT05715229

Phase2, Recruiting

Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Unipolar Depression
Location: Columbus OH
Sponsor: Alan Davis

Sex: All

Age: 18+

Code: NCT07216404

Phase2, Recruiting

Tarlatamab for the Treatment of Extensive Stage Small-cell Lung Cancer

for
Extensive Stage Lung Small Cell Carcinoma
Location: Columbus OH
Sponsor: Asrar Alahmadi

Sex: All

Age: 18+

Code: NCT07423585

Phase2, Recruiting

CD5-deleted Chimeric Antigen Receptor Cells (Senza5 CART5) for T Cell Non-Hodgkin Lymphoma (NHL)

for
T Cell Non-Hodgkin Lymphoma
Location: New York NY, Philadelphia PA
Sponsor: Vittoria Biotherapeutics

Sex: All

Age: 18+

Code: NCT06420089

Phase1, Recruiting

A Phase 1/2 Study of STP938 (Dencatistat) for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas

for
Lymphoma, B-Cell, Lymphoma, T-Cell
Location: New York NY, Sarasota FL, Denver CO
Sponsor: Step Pharma, SAS

Sex: All

Age: 18+

Code: NCT05463263

Phase1, Phase2, Recruiting

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

for
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 0+

Code: NCT06295965

Recruiting

A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity

for
Carcinoma, Neuroendocrine, Tumor, Neuroendocrine,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06406465

Phase2, Recruiting

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

for
B-Cell Non-Hodgkin Lymphoma,
Location: Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT03017820

Phase1, Recruiting