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Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

for
Lung Non-Small Cell Carcinoma, Malignant Solid Neoplasm,
Location: Irvine CA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05830058

Phase2, Recruiting

DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers

for
Small Cell Lung Carcinoma, Neuroendocrine Neoplasms,
Location: The Bronx NY, Baltimore MD, Richmond VA, Miami FL,
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT05882058

Phase2, Recruiting

Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

for
B-ALL, DLBCL, B ALL, Dlbcl-Ci, DLBCL Unclassifiable,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT04512716

Early_phase1, Recruiting

Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer

for
HPV-Negative Squamous Cell Carcinoma
Location: Chicago IL
Sponsor: University of Chicago

Sex: All

Age: 18+

Code: NCT06005324

Phase1, Recruiting

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Jacksonville FL, Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05541016

Phase2, Recruiting

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Loratadine for the Prevention of G-CSF-related Bone Pain

for
Stem Cell Transplant Complications
Location: Edmonton
Sponsor: AHS Cancer Control Alberta

Sex: All

Age: 18+

Code: NCT05421416

Phase2, Recruiting

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: Plexium, Inc.

Sex: All

Age: 18+

Code: NCT07284186

Phase1, Recruiting

Radiotherapy in Combination With Atezolizumab in Locally Advanced Borderline Resectable or Unresectable Cutaneous SCC

for
Locally Advanced Skin Squamous Cell Carcinoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05085496

Phase1, Recruiting

Photopheresis in Early-stage Mycosis Fungoides

for
Cutaneous T Cell Lymphoma, Mycosis Fungoides
Location: New York NY
Sponsor: Columbia University

Sex: All

Age: 18+

Code: NCT05680558

Phase2, Recruiting

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for
Renal Cell Carcinoma
Location: Boston MA, Ann Arbor MI, Houston TX, Dallas TX,
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06053658

Phase2, Recruiting

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

for
B-cell Malignancies
Location: New York NY, Hackensack NJ, Montreal, Winston-Salem NC,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06542250

Phase1, Phase2, Recruiting

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia

for
Recurrent Acute Lymphoblastic Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 15+

Code: NCT03136146

Phase2, Recruiting

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

for
Clonal Cytopenia of Undetermined Significance,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT03418038

Phase2, Recruiting

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

for
BRCA1 Mutation, POLD1 Gene Mutation, CDKN2A Mutation,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 25+

Code: NCT05420064

Recruiting

Weighted Blanket Use to Reduce Anxiety in Oncology Patients

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06089408

Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for
Carcinoma, Non-Small-Cell Lung
Location: Boston MA, Farmington CT, New Haven CT, New York NY,
Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All

Age: 18+

Code: NCT06667908

Phase2, Recruiting

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias

for
Leukemia, Lymphocytic, Chronic, B-Cell,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06364423

Phase1, Phase2, Recruiting

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

for
HPV-Associated Oropharyngeal Squamous Cell Carcinoma,
Location: Boston MA
Sponsor: Jonathan Schoenfeld, MD, MPH

Sex: All

Age: 22+

Code: NCT04900623

Phase2, Recruiting

Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)

for
Small Cell Lung Cancer Extensive Stage, Brain Metastases,
Location: Dallas TX
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18+

Code: NCT07139990

Phase1, Recruiting

Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas

for
Basal Cell Carcinoma
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT07182240

Recruiting