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Active & ResponsiveNew

CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial

for
HSIL, High Grade Squamous Intraepithelial Lesion,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 21+

Code: NCT06949800

Phase2, Recruiting
Active & Responsive

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

for
Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma,
Location: Boston MA, New York NY, Baltimore MD,
Sponsor: Carl Allen

Sex: All

Age: 0+

Code: NCT04079179

Phase2, Recruiting
Active & Responsive

Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC

for
Carcinoma, Squamous Cell
Location: Pittsburgh PA
Sponsor: Melissa Pugliano-Mauro

Sex: All

Age: 18+

Code: NCT03370406

Phase1, Recruiting
Active & Responsive

Autologous Dendritic Cell Vaccine in Kidney Cancer

for
Carcinoma, Renal Cell
Location: Pittsburgh PA
Sponsor: Jodi Maranchie

Sex: All

Age: 18+

Code: NCT05127824

Phase2, Recruiting
Active & Responsive

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

for
Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma,
Location: Seattle WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 1 - 26

Code: NCT04185038

Phase1, Recruiting

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Active & Responsive

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

for
Primary Sclerosing Cholangitis, PSC, Cholangiocarcinoma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT04753996

Recruiting
Active & Responsive

Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.

for
Carcinoma, Non-Small-Cell Lung
Location: Aurora CO, Lone Tree CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT03958565

Recruiting
Active & Responsive

SynKIR-310 for Relapsed/Refractory B-NHL

for
B Cell Lymphoma, NHL, Adult, Mantle Cell Lymphoma,
Location: New Brunswick NJ, Philadelphia PA, Atlanta GA,
Sponsor: Verismo Therapeutics

Sex: All

Age: 18+

Code: NCT06544265

Phase1, Recruiting
Active & Responsive

Prospective Assessment of HPV Associated Anogenital Pathology in Female Patients and Female Partners of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma, PAP-OP Study

for
Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: Female

Age: 18+

Code: NCT06115772

Recruiting
Active & Responsive

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

for
Lymphoma, B-Cell, Lymphoma, Non-Hodgkin (NHL),
Location: Cincinnatti OH, Chicago IL, St Louis MO, Omaha NE,
Sponsor: Umoja Biopharma

Sex: All

Age: 18+

Code: NCT06528301

Phase1, Recruiting
Active & Responsive

Blood, Urine, and Tissue Collection for Cutaneous Lymphoma, Eczema, and Atopic Dermatitis Research

for
Cutaneous T-cell Lymphoma, Sezary Syndrome, Mycosis Fungoides,
Location: Pittsburgh PA
Sponsor: University of Pittsburgh

Sex: All

Age: 18+

Code: NCT00177268

Recruiting
Active & Responsive

Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome

for
Recurrent Transformed Chronic Lymphocytic Leukemia,
Location: New York NY, Columbus OH, Salt Lake City UT
Sponsor: Aseel Alsouqi

Sex: All

Age: 18+

Code: NCT05873712

Phase2, Recruiting
Active & Responsive

Epcoritamab-CAR T Cells for Large B-cell Lymphomas

for
Lymphoma, Non-Hodgkin, Relapsed Diffuse Large B Cell Lymphoma,
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT06458439

Phase2, Recruiting
Active & Responsive

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

for
Uveal Melanoma, Cutaneous Melanoma, BAP1 Gene Mutation,
Location: Columbus OH
Sponsor: Mohamed Abdel-Rahman

Sex: All

Age: 0+

Code: NCT04792463

Recruiting
Active & Responsive

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

for
Esophageal Squamous Cell Carcinoma
Location: East Syracuse NY, Pittsburgh PA, Tucson AZ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT05319730

Phase1, Phase2, Recruiting
Active & Responsive

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for
Carcinoma, Non-Small-Cell Lung
Location: Halifax, Boston MA, Norwich CT, New Haven CT, Quebec,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06623422

Phase3, Recruiting
Active & Responsive

Nivolumab Alone or Plus Relatlimab or Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma

for
Basal Cell Carcinoma
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT03521830

Phase2, Recruiting
Active & Responsive

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

for
Oropharyngeal Squamous Cell Carcinoma, Carcinoma, Squamous Cell,
Location: Chapel Hill NC, North Charleston SC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT04564989

Recruiting
Active & Responsive

Nemtabrutinib With CAR T Therapy in Relapsed/Refractory Mantle Cell Lymphoma

for
Recurrent Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT07673367

Phase2, Recruiting
Active & Responsive

A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for
Lymphoma, Non-Hodgkin, B-cell Lymphoma,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT07101328

Phase1, Recruiting