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Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and Variant

for
Hairy Cell Leukemia, Hairy Cell Leukemia Variant
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT04815356

Phase1, Recruiting

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for
Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer,
Location: Boston MA, Commack NY, Baltimore MD, Ottawa, Toronto,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05123482

Phase1, Phase2, Recruiting

Molecularly Targeted Radionuclide Therapy Via the Integrin Alphavbeta6

for
Metastatic Nonsmall Cell Lung Cancer
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT06228482

Phase1, Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

for
Non-small Cell Lung Cancer (NSCLC)
Location: Westbrook ME, Mississauga, Brampton, Jacksonville FL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06170788

Phase3, Recruiting

Major Complication Rate in Cancer Patients With Neutropenic Fever Potentially Eligible for a Hospital at Home Program

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04557709

Recruiting

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Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

for
T-Cell Neoplasm, Lymphoproliferative Disorders
Location: Durham NC, Columbus OH, Ann Arbor MI, Duarte CA
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 18+

Code: NCT04858256

Phase2, Recruiting

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

for
Hypogammaglobulinemia, Bacterial Infections,
Location: Greenville NC, Bethesda MD, Morrisville NC,
Sponsor: Grifols Therapeutics LLC

Sex: All

Age: 18+

Code: NCT05645107

Phase3, Recruiting

Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

for
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Location: Columbus OH, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 60+

Code: NCT06139627

Recruiting

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05010109

Recruiting

Ladarixin With Sotorasib in Advanced NSCLC

for
Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation
Location: Garden City NY, Mineola NY, New Hyde Park NY,
Sponsor: NYU Langone Health

Sex: All

Age: 18 - 70+

Code: NCT05815173

Phase1, Recruiting

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

for
Gastric Cancer, Gastro-esophageal Junction Cancer,
Location: Jacksonville FL, Rochester MN
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06005493

Phase1, Phase2, Recruiting

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

for
NSCLC (Advanced Non-small Cell Lung Cancer)
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: BlossomHill Therapeutics

Sex: All

Age: 18+

Code: NCT06706076

Phase1, Phase2, Recruiting

Gilteritinib for the Treatment of ALK NSCLC

for
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 18+

Code: NCT06225427

Phase1, Recruiting

Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06660407

Phase2, Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for
Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary,
Location: Providence RI, New Haven CT, New York NY, Baltimore MD,
Sponsor: Volastra Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05902988

Phase1, Phase2, Recruiting

Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies

for
Monoclonal Gammopathy of Undetermined Significance,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05136807

Recruiting

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

for
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05092373

Phase1, Recruiting

Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients

for
Small Cell Lung Cancer Extensive Stage
Location: Fairfax VA, Canton OH, Cincinnati OH, Fairfield OH,
Sponsor: Genprex, Inc.

Sex: All

Age: 18+

Code: NCT05703971

Phase1, Phase2, Recruiting

Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC

for
Carcinoma, Non-Small-Cell Lung
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 18+

Code: NCT06623656

Phase2, Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

for
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer,
Location: Boston MA, Lebanon NH, New York NY, New Brunswick NJ,
Sponsor: Iambic Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06253871

Phase1, Recruiting