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Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

for
Advanced Malignant Solid Neoplasm,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT04511039

Phase1, Recruiting

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

for
Metastatic Colorectal Carcinoma,
Location: The Bronx NY, Pittsburgh PA, Gainesville FL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05803382

Phase1, Recruiting

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04771520

Phase2, Recruiting

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for
Advanced Ovarian Carcinoma,
Location: Boston MA, Mineola NY, New York NY, Bethlehem PA,
Sponsor: M.D. Anderson Cancer Center

Sex: Female

Age: 18+

Code: NCT04575935

Phase3, Recruiting

Erector Spinae Block for Thoracic Surgery

for
Pulmonary Neoplasm, Pulmonary Cancer, Thoracic Diseases,
Location: Washington D.C. DC
Sponsor: George Washington University

Sex: All

Age: 18 - 70+

Code: NCT05521789

Recruiting

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Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

for
Advanced Malignant Solid Neoplasm,
Location: New Haven CT, Trumbull CT, Bethesda MD, Pittsburgh PA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05691491

Phase1, Phase2, Recruiting

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

for
Liver Cancer, Rhabdomyosarcoma, Malignant Rhabdoid Tumor,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 1 - 21

Code: NCT04715191

Phase1, Recruiting

MRI Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

for
Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm
Location: Chicago IL, Portland OR
Sponsor: University of Chicago

Sex: Male

Age: 18+

Code: NCT05710380

Recruiting

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for
Non Small Cell Lung Cancer, Glioma Glioblastoma Multiforme,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Tango Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06810544

Phase1, Phase2, Recruiting

INTERogating Cancer for Etiology, Prevention and Therapy Navigation

for
Cancer, Cancer Gene Mutation, PAN Gene Mutation,
Location: Jacksonville FL, Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06008392

Recruiting

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

for
Glioblastoma, Glioblastoma Multiforme, Glioma, Malignant, GBM,
Location: New York NY
Sponsor: Northwell Health

Sex: All

Age: 18+

Code: NCT05271240

Phase3, Recruiting

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Boston MA, Pittsburgh PA, Houston TX, Newport Beach CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12+

Code: NCT05372640

Phase1, Recruiting

Synapse 3D With Intravascular Indocyanine Green

for
Non-small Cell Lung Cancer, Primary Neoplasm
Location: Hamilton
Sponsor: St. Joseph's Healthcare Hamilton

Sex: All

Age: 18+

Code: NCT03953144

Phase1, Phase2, Recruiting

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: New York NY, Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT06518057

Phase2, Recruiting

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

for
Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC,
Location: Glen Burnie MD, Lexington KY, Omaha NE
Sponsor: Orano Med Theranostics, SAS

Sex: All

Age: 18+

Code: NCT05283330

Phase1, Recruiting

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05746325

Recruiting

Tumor Related Epilepsy

for
Epilepsy, Cancer, Brain Neoplasm
Location: Bethesda MD
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All

Age: 8 - 70+

Code: NCT02639325

Recruiting

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

for
Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer,
Location: Nashville TN, Denver CO, Los Angeles CA
Sponsor: RasCal Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04678648

Phase1, Recruiting

A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors

for
Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer
Location: Boston MA, Canton OH, Detroit MI
Sponsor: Shanghai EpimAb Biotherapeutics Co., Ltd.

Sex: All

Age: 18+

Code: NCT03797391

Phase1, Phase2, Recruiting

A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias

for
Refractory Acute Leukemia, Pediatric Relapsed
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 2 - 21

Code: NCT06397027

Phase1, Recruiting