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Adaptive Radiation for Abdominopelvic Metastases

for
Neoplasm - Soft Tissue Pelvis Malignant Secondary,
Location: Philadelphia PA
Sponsor: Fox Chase Cancer Center

Sex: All

Age: 18+

Code: NCT05880667

Phase1, Recruiting

A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects

for
Benign Centrally-Located Intracranial Tumors
Location: Washington D.C. DC, Miami FL, Houston TX
Sponsor: InSightec

Sex: All

Age: 5 - 22

Code: NCT03028246

Recruiting

VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for
Solid Tumor, Rhabdomyosarcoma
Location: Boston MA, Philadelphia PA, Cincinnati OH, Chicago IL,
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 0 - 30

Code: NCT04796012

Phase1, Phase2, Recruiting

Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)

for
Lung Neoplasm Malignant
Location: Baltimore MD, Fairfax VA, Daphne AL, Tyler TX,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06788912

Phase2, Recruiting

Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria)

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05178472

Recruiting

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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for
Adipocytic Neoplasm, Liposarcoma, Atypical Fibroxanthoma,
Location: Boston MA, Atlanta GA, Cincinnati OH, Chicago IL,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 30

Code: NCT06239272

Phase1, Phase2, Recruiting

The Impact of COVID-19 on Pulmonary Procedures

for
COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT05022446

Recruiting

Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling

for
Recurrent Childhood Acute Myeloid Leukemia,
Location: Miami FL
Sponsor: Florida International University

Sex: All

Age: 0 - 21

Code: NCT05857969

Phase1, Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

for
Locally Advanced Solid Tumors, Metastatic Solid Tumors,
Location: Scarborough ME, Boston MA, Montreal, Philadelphia PA,
Sponsor: Turning Point Therapeutics, Inc.

Sex: All

Age: 0 - 25

Code: NCT04094610

Phase1, Phase2, Recruiting

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial

for
Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04693468

Phase1, Recruiting

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

for
Melanoma, Lymphoma, Solid Tumor, Classical Hodgkin Lymphoma,
Location: Boston MA, New York NY, Chicago IL, Fargo ND,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 0 - 17

Code: NCT02332668

Phase1, Phase2, Recruiting

Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases

for
Neoplasm Metastasis, Spinal Cord Diseases,
Location: Detroit MI
Sponsor: Henry Ford Health System

Sex: All

Age: 18+

Code: NCT05023772

Recruiting

The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

for
Recurrent Respiratory Papillomatosis, Pulmonary Neoplasm
Location: New Haven CT
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 70+

Code: NCT06412172

Recruiting

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06640010

Recruiting

Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning

for
Locally Advanced Malignant Solid Neoplasm,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT04515810

Recruiting

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

for
Advanced Malignant Solid Neoplasm,
Location: Bethesda MD, Richmond VA, Charlottesville VA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05327010

Phase2, Recruiting

Telehealth Intervention for Improving Distress and Financial Toxicity in the Caregivers

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Winston-Salem NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06709404

Recruiting

68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.

for
CNS Tumors, Meningioma, Esthesioneuroblastoma, Hemangioblastoma,
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 18 - 70+

Code: NCT04081701

Recruiting

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

for
Hematologic Malignancy, Leukemia, Lymphoma,
Location: Cincinnati OH, Milwaukee WI, Houston TX, Aurora CO
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 0 - 38

Code: NCT06131801

Recruiting

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

for
Metastatic Malignant Solid Neoplasm,
Location: Boston MA, Mineola NY, New York NY, Bethesda MD,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05687110

Phase1, Recruiting