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A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 2 - 18

Code: NCT06191978

Phase1, Recruiting

UNC Childhood, Adolescent, and Young Adult Cancer Cohort

for
Pediatric Cancer, Cancer, Cancer Metastatic, Survivorship
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 1 - 39

Code: NCT05096923

Recruiting

Digital Art Therapy for Young Cancer Survivors

for
Cancer, Pediatric Cancer, Pediatric Malignancies,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18 - 25

Code: NCT06789666

Recruiting

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Boston MA, St Louis MO
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07137416

Phase1, Recruiting

Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

for
Pancreatic Adenocarcinoma, Metastatic Pancreatic Cancer,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06483555

Phase1, Phase2, Recruiting

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Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

for
Carcinoma of Unknown Primary,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03010150

Recruiting

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for
Ovarian Cancer, Endometrial Cancer, Germ Cell Tumor,
Location: The Bronx NY, New York NY, Hackensack NJ,
Sponsor: Xencor, Inc.

Sex: All

Age: 15+

Code: NCT06276491

Phase1, Recruiting

NSAID Use After Robotic Partial Nephrectomy

for
Kidney Cancer, Renal Cancer, Renal Neoplasm
Location: Miami FL
Sponsor: University of Miami

Sex: All

Age: 18 - 70+

Code: NCT05842044

Phase2, Recruiting

Tempus Open Link for Individual Voices in Innovative Analytics Registry: Platform Protocol for Multimodal Real-World Evidence in Cancer

for
Cancer, Solid Tumor Cancer, Pediatric Acute Myeloid Leukemia,
Location: Chicago IL
Sponsor: Tempus AI

Sex: All

Age: 0+

Code: NCT07756034

Recruiting

Adapting The Fear Of Recurrence Therapy (FORT) for Parents and Establishing Acceptability and Feasibility

for
Cancer, Parent, Fear of Cancer Recurrence, CBT,
Location: Ottawa
Sponsor: University of Ottawa

Sex: All

Age: 18+

Code: NCT06872840

Recruiting

Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)

for
Relapsed Non Hodgkin Lymphoma, Relapsed Adult ALL,
Location: Edmonton
Sponsor: University of Alberta

Sex: All

Age: 2 - 70

Code: NCT03938987

Phase1, Phase2, Recruiting

Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders

for
Ampullary Cancer, Duodenal Cancer, Bile Duct Cancer,
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 18+

Code: NCT01438385

Recruiting

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells

for
Ovary Neoplasm, Ovarian Cancer, Epithelial Ovarian Cancer,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female

Age: 18+

Code: NCT06305299

Phase1, Recruiting
New

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants

for
CKD Stage 3, CKD Stage 4, Secondary Hyperparathyroidism, VDI
Location: Greenville SC
Sponsor: OPKO Health, Inc.

Sex: All

Age: 0 - 17

Code: NCT07494045

Phase2, Recruiting

Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for
Malignant Solid Neoplasm
Location: Marshalltown IA, Ames IA, Boone IA, Fort Dodge IA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT04871542

Recruiting

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

for
Glioblastoma Multiforme, Anaplastic Astrocytoma,
Location: Miami FL
Sponsor: University of Miami

Sex: All

Age: 1 - 21

Code: NCT05956821

Phase1, Phase2, Recruiting

Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells

for
Glioblastoma Multiforme, Glycolytic Index,
Location: Los Angeles CA
Sponsor: Jonsson Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06059690

Phase1, Phase2, Recruiting

Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 16+

Code: NCT04879121

Phase2, Recruiting

Studying TAK-243 in Patients With Advanced Cancer

for
Advanced Lymphoma, Advanced Malignant Solid Neoplasm,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06223542

Phase1, Recruiting

Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer

for
Malignant Neoplasm
Location: Jersey City NJ, New Brunswick NJ
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 1+

Code: NCT02688517

Recruiting