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Educational Tools for the Improvement of Early Advance Care Planning in Adolescents and Young Adults With Advanced Solid Tumors and High-Grade Brain Tumors

for
Advanced Malignant Solid Neoplasm, Malignant Brain Neoplasm,
Location: Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 39

Code: NCT07174661

Recruiting

A Study of ASP3082 in Adults With Advanced Solid Tumors

for
Solid Tumor
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: Astellas Pharma Inc

Sex: All

Age: 18+

Code: NCT05382559

Phase1, Recruiting

A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

for
Solid Tumor
Location: Providence RI, New York NY, Hackensack NJ, Newark DE,
Sponsor: Sanofi

Sex: All

Age: 18+

Code: NCT05584670

Phase1, Phase2, Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

for
Lung Cancer, Breast Cancer
Location: Hackensack NJ, Montreal, Ottawa, Miami FL, Cleveland OH,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06618287

Phase1, Phase2, Recruiting

ZZ06 in Adult Patients With Advanced Solid Tumor Malignancies

for
Advanced EGFR Positive Solid Tumor
Location: The Bronx NY, Fairway KS, Los Angeles CA
Sponsor: Changchun Intellicrown Pharmaceutical Co. LTD

Sex: All

Age: 18+

Code: NCT04412616

Phase1, Recruiting

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JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Philadelphia PA, Fairfax VA, Durham NC, Orlando FL,
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06108050

Phase1, Recruiting

A Study of ASP1002 in Adults for Treatment of Solid Tumors

for
Advanced Solid Tumors
Location: Plainville CT, New Haven CT, New York NY, Fairfax VA,
Sponsor: Astellas Pharma Global Development, Inc.

Sex: All

Age: 18+

Code: NCT05719558

Phase1, Recruiting

JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

for
Solid Tumors, ER+ Breast Cancer,
Location: Detroit MI, St Louis MO, Dallas TX, Salt Lake City UT
Sponsor: Jacobio Pharmaceuticals Co., Ltd.

Sex: All

Age: 18+

Code: NCT05490472

Phase1, Phase2, Recruiting

A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations

for
Advanced Solid Tumors With MAPK Pathway Mutations
Location: Detroit MI, Nashville TN, Houston TX
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT05886920

Phase1, Phase2, Recruiting

A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

for
Advanced Solid Tumors
Location: Fairfax VA, Huntersville NC, San Antonio TX
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07161414

Phase1, Recruiting

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

for
Advanced Solid Tumors
Location: Cleveland OH, St Louis MO, Rochester MN,
Sponsor: Jacobio Pharmaceuticals Co., Ltd.

Sex: All

Age: 18+

Code: NCT06973564

Phase1, Phase2, Recruiting

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors

for
ER+, HER 2- Breast Cancer, Non-small Cell Lung Cancer (NSCLC),
Location: Lake Success NY, East Brunswick NJ, Fairfax VA,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18 - 70+

Code: NCT07540572

Phase1, Recruiting

First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

for
Neoplasms
Location: Toronto, Montreal, Philadelphia PA, San Antonio TX
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07438782

Phase1, Recruiting

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

for
Hepatoblastoma, Hepatocellular Carcinoma, Wilms Tumor,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 0 - 21

Code: NCT06198296

Phase1, Recruiting

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for
HR+ Breast Cancer, Triple Negative Breast Cancer (TNBC),
Location: Boston MA, New Haven CT, Fairfax VA, Morgantown WV,
Sponsor: NiKang Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07029399

Phase1, Recruiting
New

SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors

for
Selected Advanced Solid Tumors, Colorectal Cancer (CRC),
Location: Glen Burnie MD
Sponsor: SK Life Science, Inc.

Sex: All

Age: 18+

Code: NCT07812805

Phase1, Recruiting

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

for
Squamous Non-small-cell Lung Cancer,
Location: New Haven CT, Hackensack NJ, Fairfax VA, Louisville KY,
Sponsor: Alentis Therapeutics AG

Sex: All

Age: 18+

Code: NCT06747585

Phase1, Phase2, Recruiting

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic Solid Tumor
Location: Lake Success NY, East Brunswick NJ, Fairfax VA,
Sponsor: Pliant Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06270706

Phase1, Recruiting

A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

for
Advanced or Metastatic Solid Tumors
Location: New Haven CT, Philadelphia PA, Baltimore MD, Fairfax VA,
Sponsor: Takeda

Sex: All

Age: 18+

Code: NCT07205718

Phase1, Phase2, Recruiting

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic Solid Tumors,
Location: San Antonio TX, Scottsdale AZ
Sponsor: SHY Therapeutics

Sex: All

Age: 18+

Code: NCT07705334

Phase1, Recruiting