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A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

for
Tumours, Gynecological
Location: Toronto, Montreal, Rochester NY, Durham NC, Columbus OH,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT06796907

Phase1, Phase2, Recruiting

A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-001)

for
Metastatic Neoplasm
Location: Hackensack NJ, Chicago IL, Houston TX
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07030712

Phase1, Recruiting

A Study of ZW251 in Participants With Advanced Solid Tumors

for
Hepatocellular Carcinoma,
Location: New York NY, Hackensack NJ, Louisville KY,
Sponsor: Zymeworks BC Inc.

Sex: All

Age: 18+

Code: NCT07164313

Phase1, Recruiting

ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors

for
HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer
Location: New York NY, Sarasota FL, Houston TX, New Haven CT,
Sponsor: Avenzo Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06998407

Phase1, Phase2, Recruiting

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor

for
Advanced Liver Cancer
Location: New York NY, Jacksonville FL, Tampa FL, Rochester MN,
Sponsor: Abbisko Therapeutics Co, Ltd

Sex: All

Age: 18 - 70+

Code: NCT04906434

Phase1, Recruiting

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A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

for
Cervical Squamous Cell Carcinoma,
Location: New Haven CT, Hackensack NJ, Fairfax VA, Louisville KY,
Sponsor: Alentis Therapeutics AG

Sex: All

Age: 18+

Code: NCT07169734

Phase1, Phase2, Recruiting

A Study of JNJ-1761981 in Participants With Solid Tumors

for
Neoplasms
Location: The Bronx NY, Jacksonville FL, Rochester MN, Houston TX
Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All

Age: 18+

Code: NCT07525141

Phase1, Recruiting

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for
Urothelial Carcinoma Bladder,
Location: New York NY, Glen Burnie MD, Miami FL, Pittsburgh PA,
Sponsor: Aktis Oncology, Inc.

Sex: All

Age: 18+

Code: NCT07020117

Phase1, Recruiting

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors

for
ER+, HER 2- Breast Cancer, Non-small Cell Lung Cancer (NSCLC),
Location: Lake Success NY, East Brunswick NJ, Fairfax VA,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18 - 70+

Code: NCT07540572

Phase1, Recruiting

A Study of BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer

for
Diffuse Pleural Mesothelioma, Gastroesophageal Carcinoma,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07532902

Phase1, Recruiting

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

for
Head and Neck Squamous Cell Carcinoma (HNSCC),
Location: New York NY, Columbus OH, Grand Rapids MI,
Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT05985655

Phase1, Phase2, Recruiting

A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

for
Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma,
Location: Lake Success NY, Hackensack NJ, Fairfax VA, Durham NC,
Sponsor: Astellas Pharma Global Development, Inc.

Sex: All

Age: 18+

Code: NCT07488676

Phase1, Phase2, Recruiting

First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

for
Neoplasms
Location: Toronto, Montreal, Philadelphia PA, San Antonio TX
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07438782

Phase1, Recruiting

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

for
Malignant Neoplasm
Location: Boston MA, New Haven CT, Valhalla NY, New York NY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 0 - 17

Code: NCT06941272

Phase1, Phase2, Recruiting

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

for
Mesothelioma, Neoplasms, Stomach Neoplasms,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06885697

Phase1, Recruiting

AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

for
Advanced Melanoma and Normal or Impaired, Advanced Melanoma
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT07027488

Phase1, Recruiting

A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

for
Malignant Neoplasm
Location: Sherbrooke, New York NY, Hackensack NJ, Montreal,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06979596

Phase2, Recruiting

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

for
Hepatoblastoma, Hepatocellular Carcinoma, Wilms Tumor,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 0 - 21

Code: NCT06198296

Phase1, Recruiting

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

for
Sarcoma, Endocrine Tumors, Neuroblastoma, Retinoblastoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0+

Code: NCT01109394

Recruiting

Tumor Infiltrating Lymphocyte Therapy for Pediatric High Risk Solid Tumors

for
Lymphocytes
Location: St. Petersburg FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 1 - 21

Code: NCT06047977

Phase1, Recruiting