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Active & Responsive

Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Progressive Osteosarcoma

for
Osteosarcoma
Location: Cleveland OH
Sponsor: MedPacto, Inc.

Sex: All

Age: 12+

Code: NCT05588648

Phase 1, Phase 2, Recruiting
Active & Responsive

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

for
Breast Neoplasms
Location: Rimouski, Boston MA, Quebec, Stony Brook NY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06312176

Phase 3, Recruiting
Active & Responsive

Home-based Vision Rehabilitation Guided by Brain Imaging

for
Visual Field Defect, Stroke, Hemianopia Homonymous,
Location: Washington D.C. DC
Sponsor: Georgetown University

Sex: All

Age: 18+

Code: NCT07635329

Recruiting
Active & Responsive

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for
Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma
Location: Brewer ME, Scarborough ME, Boston MA, Providence RI,
Sponsor: National Cancer Institute (NCI)

Sex: Female

Age: 18+

Code: NCT07198074

Phase 3, Recruiting
Active & Responsive

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

for
Intestinal Neoplasms, Gastrointestinal Neoplasms,
Location: Topsham ME, Westbrook ME, Boston MA, Newton MA,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07222800

Phase 3, Recruiting

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Active & Responsive

REVerse Intestinal Metaplasia in the Stomach (REVISE)

for
Gastric Intestinal Metaplasia, Gastric Precancer
Location: Durham NC
Sponsor: Katherine Garman

Sex: All

Age: 18+

Code: NCT06590454

Phase 2, Recruiting
Active & Responsive

Statewide Optimization of Lung Cancer Screening Utilizing the QUILSâ„¢ System in Nevada and Mississippi: State-Based Initiative Component

for
Lung Cancer Screening
Location: Tupelo MS, New Albany MS, Gulfport MS, Hattiesburg MS,
Sponsor: Timothy Mullett

Sex: All

Age: 18 - 70+

Code: NCT07682597

Recruiting
Active & Responsive

Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for
Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC,
Location: New York NY, Belleville NJ, East Brunswick NJ,
Sponsor: Immuneering Corporation

Sex: All

Age: 18+

Code: NCT07562152

Phase 3, Recruiting
Active & Responsive

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

for
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06868433

Phase 1, Recruiting
Active & Responsive

HER2 Vaccine for Locally Advanced Breast Cancer

for
Breast Cancer, HER2-positive Breast Cancer
Location: Indianapolis IN
Sponsor: Pravin T.P Kaumaya

Sex: All

Age: 18+

Code: NCT06949410

Phase 1, Recruiting
Active & Responsive

Biobank for Cholestatic Liver Diseases.

for
Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT03445585

Recruiting
Active & Responsive

HER-2 B Cell Peptide Vaccine

for
Metastatic Breast Cancer, HER2-positive Breast Cancer,
Location: Indianpolis IN
Sponsor: Pravin T.P Kaumaya

Sex: All

Age: 18+

Code: NCT06414733

Phase 1, Recruiting
Active & Responsive

Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform

for
Shwachman-Diamond Syndrome, SDS, IBMF, Congenital Neutropenia,
Location: Woburn MA
Sponsor: Shwachman-Diamond Syndrome Alliance Inc

Sex: All

Age: 0+

Code: NCT06999954

Recruiting
Active & Responsive

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for
Ovarian Cancer, Fallopian Tube Cancer
Location: Boston MA, New York NY, Philadelphia PA, Durham NC,
Sponsor: M.D. Anderson Cancer Center

Sex: Female

Age: 18+

Code: NCT05287451

Recruiting
Active & Responsive

WBSI Guided Personalized Delivery of TTFields

for
GBM, Glioma Glioblastoma Multiforme, Tumor, Brain
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 22+

Code: NCT05086497

Recruiting
Active & Responsive

Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)

for
Breast Cancer
Location: Columbus OH, Chicago IL, Iowa City IA
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT06169371

Recruiting
Active & Responsive

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for
Metastatic Dedifferentiated Liposarcoma,
Location: Boston MA, Waterford CT, Guilford CT, New Haven CT,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06422806

Phase 3, Recruiting
Active & Responsive

A Phase 1/2 Study of BHV-1510 (Previously PBI-410) in Advanced Solid Tumors

for
Solid Tumor
Location: New York NY, Philadelphia PA, Washington D.C. DC,
Sponsor: Biohaven Therapeutics Ltd.

Sex: All

Age: 18+

Code: NCT06384807

Phase 1, Phase 2, Recruiting
Active & Responsive

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

for
Advanced Esophageal Adenocarcinoma,
Location: Westerly RI, Waterford CT, Guilford CT, Glastonbury CT,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06203600

Phase 2, Phase 3, Recruiting
Active & Responsive

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for
Clinical Stage III Cutaneous Melanoma AJCC v8,
Location: Springfield MA, Saint Johnsbury VT, Lebanon NH,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05136196

Phase 2, Recruiting