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Active & Responsive

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

for
Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis,
Location: Los Altos CA
Sponsor: xCures

Sex: All

Age: 0+

Code: NCT06539169

Recruiting
Active & Responsive

US Benchmarking Clinical Study

for
HFpEF - Heart Failure With Preserved Ejection Fraction, HFmrEF,
Location: Boston MA
Sponsor: eMyosound SAS

Sex: All

Age: 60+

Code: NCT07215715

Recruiting
Active & Responsive

Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers

for
Amyloidosis, Hereditary, Amyloidosis Cardiac,
Location: New York NY, Cleveland OH, Dallas TX
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 30 - 70+

Code: NCT05489549

Recruiting
Active & Responsive

Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis

for
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis,
Location: St Louis MO
Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All

Age: 18 - 70+

Code: NCT07695701

Recruiting

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for
Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Location: Boston MA, New Haven CT, Manhasset NY, Rosedale NY,
Sponsor: Novo Nordisk A/S

Sex: All

Age: 18+

Code: NCT07207811

Phase3, Recruiting

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Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy

for
Amyloid Cardiomyopathy
Location: London
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All

Age: 40 - 70+

Code: NCT06634108

Phase1, Phase2, Recruiting
New

Long-term Safety of Eplontersen Treated aTTR Patients and in Liver Transplant and Severely Hepatic Impaired Subpopulations

for
Transthyretin Amyloidosis,
Location: Vancouver, Los Angeles CA
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07654855

Recruiting

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

for
Transthyretin Amyloidosis, Heart Failure,
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 65+

Code: NCT05577819

Recruiting

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for
Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis,
Location: Boston MA, New Haven CT, Rosedale NY, New York NY,
Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All

Age: 18 - 70+

Code: NCT06563895

Phase3, Recruiting

Exercise Training in Transthyretin Cardiac Amyloidosis

for
Amyloid Cardiomyopathy, Transthyretin Cardiac Amyloidosis
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 60 - 70+

Code: NCT05797857

Recruiting

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

for
Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN, ATTR, ATTR-Mixed,
Location: Halifax, Boston MA, New Haven CT, Manhasset NY,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT06465810

Recruiting

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

for
Transthyretin Amyloidosis With Cardiomyopathy
Location: Boston MA, New Brunswick NJ, Philadelphia PA,
Sponsor: Alnylam Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07358078

Recruiting

Multicenter Study for the Validation of an AI-based ECG Platform for Early Cardiac Amyloidosis Diagnosis

for
Transthyretin Cardiac Amyloidosis
Location: Evanston IL
Sponsor: Idoven 1903 S.L.

Sex: All

Age: 18+

Code: NCT06978660

Recruiting

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

for
Transthyretin Amyloidosis With Cardiomyopathy
Location: Boston MA, Norwich CT, Manhasset NY, The Bronx NY,
Sponsor: Alnylam Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT07052903

Phase3, Recruiting

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Location: Boston MA, New Haven CT, New York NY, Montreal,
Sponsor: Intellia Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06128629

Phase3, Recruiting

Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

for
Amyloidosis, Transthyretin Amyloidosis
Location: Portland OR
Sponsor: Oregon Health and Science University

Sex: All

Age: 40 - 70+

Code: NCT05758493

Phase2, Recruiting

CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study

for
Cardiac Amyloidosis
Location: Charlotte NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06096675

Recruiting

Cardiovascular Multimodality Imaging Study

for
Non-ischemic Cardiomyopathy, Cardiomyopathies,
Location: The Bronx NY
Sponsor: Montefiore Medical Center

Sex: All

Age: 18+

Code: NCT06610019

Recruiting

Ultrasound Therapy In Cardiac Amyloidosis

for
Amyloidosis Cardiac
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18 - 70+

Code: NCT04667494

Recruiting

[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy

for
Cardiac Amyloidosis
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18+

Code: NCT07560306

Phase3, Recruiting