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Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

for
Treatment Resistant Depression, Epilepsy
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 22 - 70

Code: NCT05418894

Recruiting

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

for
Treatment Resistant Depression (TRD),
Location: San Diego CA
Sponsor: University of California, San Diego

Sex: All

Age: 18 - 70+

Code: NCT07217223

Recruiting

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

for
Healthy, Major Depressive Disorder,
Location: Houston TX
Sponsor: Texas A&M University

Sex: All

Age: 21 - 45

Code: NCT06480201

Phase1, Recruiting

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

for
Treatment Resistant Depression (TRD)
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT07563868

Recruiting

Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression

for
Treatment-Resistant Depression, Bipolar Depression
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18 - 65

Code: NCT07108257

Recruiting

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Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression

for
Treatment-Resistant Depression,
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18 - 65

Code: NCT07094789

Recruiting

Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI

for
Suicidal Ideation, Treatment-resistant Depression
Location: San Diego CA
Sponsor: University of California, San Diego

Sex: All

Age: 18 - 70

Code: NCT05377177

Recruiting

ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression

for
Treatment Resistant Depression, Ketamine
Location: Saskatoon
Sponsor: University of Saskatchewan

Sex: All

Age: 18+

Code: NCT03272698

Recruiting

Deep Brain Stimulation for Treatment Resistant Depression

for
Treatment Resistant Depression
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 20 - 70+

Code: NCT04009928

Phase1, Phase2, Recruiting

DBS for Depression

for
Treatment Resistant Depression
Location: Queens NY
Sponsor: Northwell Health

Sex: All

Age: 18 - 65

Code: NCT06096207

Phase1, Recruiting

Physical Activity Program for TRD

for
Treatment-resistant Depression, Major Depressive Disorder
Location: Toronto
Sponsor: Unity Health Toronto

Sex: All

Age: 18 - 65

Code: NCT06404320

Recruiting

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

for
Suicide, Depressive Disorder, Treatment-Resistant, Ketamine,
Location: Bethesda MD
Sponsor: National Institute of Mental Health (NIMH)

Sex: All

Age: 18 - 70

Code: NCT06511908

Phase2, Recruiting

rTMS With and Without Text4Support for the Treatment of Resistant Depression.

for
Depressive Disorder, Treatment-Resistant
Location: Halifax, Edmonton
Sponsor: University of Alberta

Sex: All

Age: 18+

Code: NCT05570344

Recruiting

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

for
Depressive Disorder, Treatment-Resistant
Location: New York NY, Skokie IL, Redlands CA
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT07716098

Phase3, Recruiting

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

for
Depressive Disorder, Major,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18 - 65

Code: NCT02994433

Phase1, Recruiting

Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression

for
Late Life Depression (LLD),
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 60+

Code: NCT06854367

Recruiting

Brain Stimulation for Severe Depression

for
Depression Severe
Location: St Louis MO
Sponsor: Inner Cosmos Inc

Sex: All

Age: 21 - 70+

Code: NCT05393622

Recruiting

Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)

for
Depression, Sleep Apnea, Obstructive
Location: Kingston
Sponsor: Queen's University

Sex: All

Age: 18 - 65

Code: NCT00441636

Recruiting

Accelerated Bilateral Sequential Theta Burst Stimulation in Older Adults With Treatment-resistant Depression

for
Depressive Disorder, Treatment-Resistant
Location: Toronto
Sponsor: Ontario Shores Centre for Mental Health Sciences

Sex: All

Age: 50+

Code: NCT06323486

Recruiting

Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study

for
Major Depressive Disorder (MDD), Major Depressive Episode,
Location: Toronto
Sponsor: Unity Health Toronto

Sex: All

Age: 18+

Code: NCT06732089

Recruiting