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Active & Responsive

Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression

for
Treatment-Resistant Depression
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 18 - 70

Code: NCT07211438

Phase2, Recruiting
Active & Responsive

Characterizing Synaptic Density in Treatment Resistant Depression

for
Treatment Resistant Depression,
Location: Toronto
Sponsor: Unity Health Toronto

Sex: All

Age: 25 - 65

Code: NCT03537794

Recruiting
Active & Responsive

PCS in Severe Treatment Resistant Depression

for
Treatment Resistant Depression
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 22 - 70

Code: NCT04124341

Recruiting
Active & Responsive

Psilocybin rTMS for Treatment Resistant Depression

for
Treatment Resistant Depression, MDD, Major Depressive Disorder,
Location: Austin TX
Sponsor: University of Texas at Austin

Sex: All

Age: 22 - 65

Code: NCT06132178

Phase2, Recruiting
Active & Responsive

Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression

for
Major Depressive Disorder (MDD),
Location: Ottawa
Sponsor: The Royal Ottawa Mental Health Centre

Sex: All

Age: 18 - 70+

Code: NCT06773949

Recruiting

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Active & Responsive

Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

for
Treatment Resistant Depression
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 18 - 65

Code: NCT06512220

Phase2, Recruiting
Active & Responsive

Mindfulness Engaged Neurostimulation for Depression (MEND II)

for
Depression, Treatment Resistant Depression,
Location: San Diego CA
Sponsor: University of California, San Diego

Sex: All

Age: 18 - 65

Code: NCT07512284

Phase2, Recruiting
Active & Responsive

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for
Treatment Resistant Depression
Location: Boston MA, Nashua NH, New York NY, Woodbury NY,
Sponsor: LivaNova

Sex: All

Age: 18+

Code: NCT03887715

Recruiting
Active & Responsive

Intravenous Ketamine for Treatment-Resistant Depression

for
Depressive Disorder, Treatment-Resistant,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 65

Code: NCT06668571

Phase2, Recruiting
Active & Responsive

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for
Treatment Resistant Depression
Location: Boston MA, New York NY, New Brunswick NJ,
Sponsor: Abbott Medical Devices

Sex: All

Age: 22 - 70

Code: NCT06423430

Recruiting
Active & Responsive

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

for
Treatment Resistant Depression
Location: Watertown MA, Springfield MA, Eatontown NJ, New York NY,
Sponsor: atai Therapeutics, Inc.

Sex: All

Age: 18 - 65

Code: NCT06524830

Phase2, Recruiting
Active & ResponsiveNew

One-Day cTBS Over the Precuneus

for
Depressive Disorder, Treatment-Resistant,
Location: Belmont MA
Sponsor: Mclean Hospital

Sex: All

Age: 18+

Code: NCT07758010

Recruiting
Active & Responsive

The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder

for
Depression, Treatment Resistant Depression
Location: Calgary
Sponsor: University of Calgary

Sex: All

Age: 18 - 65

Code: NCT04805879

Phase2, Phase3, Recruiting
Active & Responsive

DBS for TRD With the Medtronic Percept PC

for
Major Depressive Disorder, Treatment Resistant Depression
Location: New York NY
Sponsor: Helen Mayberg, MD

Sex: All

Age: 25 - 70

Code: NCT05773755

Recruiting
Active & Responsive

Lumateperone for Late-Life Depression

for
Treatment Resistant Depression (TRD),
Location: St Louis MO
Sponsor: Eric Lenze

Sex: All

Age: 60+

Code: NCT07623135

Phase3, Recruiting
Active & Responsive

rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression

for
Depression, Treatment Resistant
Location: Indianapolis IN
Sponsor: Indiana University

Sex: All

Age: 18 - 70

Code: NCT06511544

Recruiting
Active & Responsive

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

for
Major Depressive Disorder (MDD),
Location: Watertown MA, Worcester MA, Brooklyn NY, Cary NC,
Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All

Age: 18 - 65

Code: NCT07284667

Phase2, Recruiting
Active & Responsive

Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)

for
Borderline Personality Disorder (BPD),
Location: Toronto
Sponsor: Joshua Rosenblat

Sex: All

Age: 18 - 70

Code: NCT07569198

Phase2, Recruiting
Active & Responsive

E-field Guided iTBS for Treatment Resistant Depression

for
Major Depressive Disorder
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 18 - 65

Code: NCT05583747

Recruiting
Active & ResponsiveNew

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

for
Major Depression
Location: Philadelphia PA, Birmingham AL, Tuscaloosa AL,
Sponsor: VA Office of Research and Development

Sex: All

Age: 18 - 70+

Code: NCT07226232

Phase3, Recruiting