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FeaturedActive & Responsive

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

for
Metastatic Breast Cancer
Location: Durham NC, Chattanooga TN, Nashville TN, Zion IL,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT03424005

Phase1, Phase2, Recruiting
FeaturedActive & Responsive

A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)

for
Neuromyelitis Optica Spectrum Disorder, NMOSD
Location: Denver CO
Sponsor: Hoffmann-La Roche

Sex: All

Age: 2 - 11

Code: NCT05199688

Phase3, Recruiting
FeaturedActive & Responsive

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for
Moderately to Severely Active Crohns Disease
Location: Boston MA, Providence RI, North Massapequa NY,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 16 - 70+

Code: NCT06819878

Phase3, Recruiting
FeaturedNew

Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease

for
Parkinson's Disease
Location: Georgetown TX
Sponsor: AbbVie

Sex: All

Age: 18 - 70+

Code: NCT07227896

Recruiting
FeaturedNew

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

for
Obesity, Overweight
Location: Morehead City NC, Newport News VA, New Bern NC,
Sponsor: AbbVie

Sex: All

Age: 18 - 70+

Code: NCT07752979

Phase2, Recruiting

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A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma

for
Multiple Myeloma
Location: New York NY, Newark DE, Fairfax VA, Chapel Hill NC,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT05650632

Phase1, Recruiting
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A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma

for
Mature B-Cell Non-Hodgkin Lymphoma
Location: Boston MA, New York NY, Baltimore MD, Cincinnati OH,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 0 - 30

Code: NCT05533775

Phase1, Phase2, Recruiting
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A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer,
Location: Boston MA, Philadelphia PA, Charlotte NC, Germantown TN,
Sponsor: Hoffmann-La Roche

Sex: Female

Age: 18+

Code: NCT04802759

Phase1, Phase2, Recruiting
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A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant

for
Multiple Myeloma
Location: New York NY, Fairfax VA, Chapel Hill NC, Roanoke VA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07095452

Phase2, Phase3, Recruiting
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A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma

for
Lymphoma
Location: New Haven CT, Stony Brook NY, New Brunswick NJ,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06084936

Phase3, Recruiting
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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for
Crohn's Disease
Location: New Bedford MA, New Haven CT, Quebec, Danbury CT,
Sponsor: AbbVie

Sex: All

Age: 18 - 70+

Code: NCT06548542

Phase2, Recruiting
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Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

for
Endometriosis
Location: Belmont MA
Sponsor: Mclean Hospital

Sex: Female

Age: 21+

Code: NCT06477406

Phase2, Recruiting
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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

for
Hemophilia A
Location: Hamilton, Indianapolis IN, Iowa City IA, Vancouver,
Sponsor: Hoffmann-La Roche

Sex: Male

Age: 2 - 59

Code: NCT05987449

Phase1, Phase2, Recruiting
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A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia

for
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Location: Columbus OH, Rochester MN, Salt Lake City UT
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT05091424

Phase1, Recruiting
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A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

for
Primary Open Angle Glaucoma
Location: Reading MA, New York NY, Philadelphia PA,
Sponsor: AbbVie

Sex: All

Age: 45+

Code: NCT06822738

Phase3, Recruiting
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A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

for
Advanced Prostate Cancer, Metastatic Prostate Cancer
Location: New Haven CT, Orlando FL, Toronto, Nashville TX,
Sponsor: Genentech, Inc.

Sex: Male

Age: 18+

Code: NCT05800665

Phase1, Recruiting
Featured

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

for
Muscular Atrophy, Spinal
Location: New York NY, Philadelphia PA, Gainesville FL,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 0 - 2

Code: NCT05861986

Recruiting
Featured

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for
Huntington Disease
Location: Boston MA, Philadelphia PA, Pittsburgh PA, Columbus OH,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 25 - 65

Code: NCT06826612

Phase1, Phase2, Recruiting
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A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

for
Non-cystic Fibrosis Bronchiectasis,
Location: Chapel Hill NC, Pittsburgh PA, Birmingham AL,
Sponsor: Genentech, Inc.

Sex: All

Age: 18+

Code: NCT06603246

Phase1, Recruiting
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A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for
Non Small Cell Lung Cancer
Location: Levis, Greenfield Park, Montreal, Brampton,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT04928846

Phase3, Recruiting