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A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older Adults
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
What RSV vaccine clinical trials are studying now
Combination vaccines. RSV and human metapneumovirus, or hMPV, cause similar illness in older adults. Sanofi and GSK are both testing single vaccines that cover both viruses.
Revaccination. The CDC currently recommends a single dose, with no second dose for now. Trials are measuring how protection holds up over several seasons and whether a later dose helps.
People with weakened immune systems. Studies of the approved vaccines in people who had a transplant or take immune suppressing medicines, who may respond differently and were not the focus of the original trials.
Pregnancy. One vaccine is approved during weeks 32 to 36 of pregnancy so antibodies pass to the baby. A Phase 3 study now asks whether vaccination should be repeated in a later pregnancy.
Infants. Two long acting antibodies protect babies through their first RSV season. Current infant studies focus on real world safety. Trials of actual vaccines in children under 2 are limited in the US, because in 2024 a study of two experimental vaccines saw more severe RSV in vaccinated infants than in the placebo group, and the FDA paused enrollment of that age group while it reviews the science.
Not sure whether your symptoms are RSV? Read our guide to RSV in adults.
Who can participate in RSV vaccine clinical trials?
Most adult studies enroll people 50 or 60 and older, and many specifically want people with a chronic heart, lung, or kidney condition, because they are at higher risk from RSV. Some studies enroll adults who already received an RSV vaccine, to test a second dose, and others enroll people who have not. Immunocompromised studies want people with a transplant or on immune suppressing treatment. Pregnancy studies enroll people in a specific window of pregnancy. Infant antibody studies enroll babies through their parents. Vaccine trials are usually randomized and often placebo controlled, so some participants receive an inactive shot, and no one is promised the vaccine. Eligibility always varies by study; our guide to eligibility criteria explains the terms.
Had a transplant? See RSV vaccines for transplant patients.
Do RSV vaccine trial participants get paid?
Some studies offer compensation for time and travel, and study related visits and tests are typically provided at no cost to participants. Compensation varies by trial and is always described during the informed consent process before you agree to anything.
Curious whether clinical trials pay participants? Here's how compensation actually works.
How often do you get the RSV vaccine?
For now, once. The CDC says the RSV vaccine is not an annual vaccine, and people who already received a dose, including in a past season, should not get another at this time. Whether a later dose will be needed is exactly what revaccination trials are studying.
Is the RSV vaccine safe?
The vaccines went through large placebo controlled trials before approval and are monitored afterward; that monitoring is how the rare Guillain Barre signal was found and added to the label. Like any vaccine, they have side effects, and the decision is one to make with your doctor. Clinical trials continue to study safety in groups such as people with weakened immune systems.
How to enroll in an RSV vaccine clinical trial
Enrolling in a clinical trial for RSV vaccines through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify Your Trial: Use our search bar or filters to find clinical trials for RSV vaccines that match your interests and needs. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select Your Preferred Location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore Study Details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the Health Profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the Application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.