Yttrium-90 (Y90) Radioembolization for the Treatment of Early Stage Renal Cell Carcinoma, The RENEGADE Trial
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age With Chronic Kidney Disease (CKD)
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Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
What are clinical trials for kidney disease?
Clinical trials for kidney disease are research studies designed to test new treatments, interventions, or diagnostic methods aimed at improving the management and outcomes of kidney conditions including kidney disease. These trials may involve experimental medications, innovative therapies, surgical techniques, or lifestyle interventions.
The importance of kidney disease clinical trials
Kidney disease clinical trials are crucial because they help advance our understanding of kidney disorders so that more effective treatments can be developed. These trials test new drugs, therapies, and diagnostic methods, aiming to improve patient outcomes, slow disease progression, and enhance quality of life.
Clinical trials for kidney disease also provide valuable data on the safety and efficacy of new interventions, which can lead to better management strategies and potential cures. Without clinical trials, the development of innovative solutions and improvements in care for kidney disease would be limited, potentially leaving patients with fewer options and suboptimal outcomes.
Types of kidney disease clinical trials
Clinical trials for kidney disease can take on many different forms. Researchers will choose the method that best suits the objectives and expected outcomes of the research.
Prevention trials
Prevention trials are designed to identify and test strategies that can prevent the onset of kidney disease in high-risk individuals, or slow its progression in those already affected. These trials typically involve interventions like lifestyle changes, new medications, dietary modifications, or supplements that may reduce the risk factors associated with kidney disease, like high blood pressure, diabetes, or obesity.
Participants in prevention trials might include people with a family history of kidney disease, those with chronic conditions known to affect kidney function, or individuals with early signs of kidney damage. The goal is to determine whether the intervention can effectively prevent kidney disease or delay its onset or progression, ultimately reducing the incidence and impact of kidney-related health issues.
Treatment trials
Treatment trials in clinical research for kidney disease are designed to evaluate the safety and effectiveness of new therapies or interventions aimed at treating the disease or its complications. These trials often focus on medications, surgical procedures, medical devices, or alternative therapies that could improve kidney function, slow disease progression, or alleviate symptoms.
Participants in treatment trials usually include individuals who have been diagnosed with kidney disease, ranging from early-stage chronic kidney disease (CKD) to more advanced stages, including those requiring dialysis or awaiting a kidney transplant. Treatment trials can also involve comparing the new treatment against standard care or a placebo to determine if it offers superior outcomes.
Quality of life trials
Quality of life (QoL) trials in kidney disease research focus on understanding and improving the overall well-being and daily functioning of patients living with the condition. These trials assess how treatments, interventions, or disease management strategies affect patients' physical, emotional, and social health.
Participants in QoL trials may include individuals at various stages of kidney disease, including those undergoing dialysis, post-transplant patients, or those managing chronic kidney disease (CKD) with medication. The interventions studied might include new therapies, psychological support programs, dietary changes, or exercise regimens.
Participation in a clinical trial for kidney disease
Participating in a clinical trial for kidney disease gives participants the opportunity to contribute to scientific research that could benefit wider society. While there are risks and considerations involved, kidney disease clinical trial participation can also offer participants a number of benefits.
Participant benefits
Access to cutting-edge treatments, close medical monitoring, and the opportunity to contribute to medical research that may benefit future patients are some of the key benefits of participating in a kidney disease clinical trial. Participants will receive treatment at no cost, gain additional support, and may even experience improved health outcomes. Involvement in a trial for kidney disease also allows patients to take an active role in their healthcare decisions.
Risks and considerations
Participating in a clinical trial for kidney disease carries risks and considerations, such as the possibility of experiencing side effects from the experimental treatment, which may be unknown or more severe than currently available therapies. There's also the chance that the treatment may not be effective, potentially leading to no improvement or worsening of the condition.
Participants may need to commit significant time for frequent medical visits and tests, and they might have to follow strict trial protocols, which can affect their daily life. Additionally, not all trial-related expenses may be covered, and there's the emotional toll of uncertainty about the trial's outcome.
Worried about the risks of participating in a clinical trial? Delve into our comprehensive guide to gain insights into the potential outcomes of participating. Learn about potential risks, benefits, and safety considerations to make an informed decision about your participation in a clinical trial.
Who can take part in a kidney disease clinical trial?
Eligibility for participating in a clinical trial for kidney disease varies depending on the specific study, but generally, individuals with a diagnosed kidney condition or those at high risk of developing one may qualify. Trials may target patients at different stages of kidney disease, from early chronic kidney disease (CKD) to those on dialysis or post-transplant.
For most trials, eligibility criteria often include factors like age, gender, medical history, current health status, and previous treatments. Some trials also seek healthy volunteers for comparison.
What to expect when participating in a clinical trial for kidney disease
When participating in a clinical trial for kidney disease, participants can expect to undergo a thorough screening process to ensure they meet the trial’s specific inclusion and exclusion criteria. Following this, a detailed informed consent will be provided where the study’s purpose, procedures, risks, and benefits are explained.
During the trial, participants may receive an experimental treatment, placebo, or standard care, with regular monitoring through medical visits, tests, and assessments to track health and the treatment’s effects.
How to enroll in a clinical trial for kidney disease
Enrolling in a clinical trial studying kidney disease through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify Your Trial: Use our intuitive search bar or filter options to locate clinical trials specific to requirements. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select Your Preferred Location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore Study Details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the Health Profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the Application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.