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Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

for
B-Cell Lymphoma, Myelodysplastic Syndromes (MDS),
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12 - 70+

Code: NCT05092451

Phase1, Phase2, Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: Houston TX
Sponsor: Taiho Oncology, Inc.

Sex: All

Age: 18+

Code: NCT04953897

Phase1, Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: Houston TX
Sponsor: Taiho Oncology, Inc.

Sex: All

Age: 18+

Code: NCT04953910

Phase1, Recruiting

Tazemetostat and Palbociclib With CPX-351for R/R AML

for
Recurrent Acute Myeloid Leukemia,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT05627232

Phase1, Recruiting

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia (AML)
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05756777

Phase1, Recruiting

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CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia

for
Acute Myeloid Leukemia, Recurrent Adult Acute Myeloid Leukemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05672147

Phase1, Recruiting

Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

for
Previously Untreated Relapsed Refractory Acute Myeloid Leukemia
Location: New York NY, Baltimore MD, Chapel Hill NC,
Sponsor: Beat AML, LLC

Sex: All

Age: 18+

Code: NCT03013998

Phase2, Phase3, Recruiting

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

for
Acute Myeloid Leukemia, Leukemia, Leukemia, Myeloid,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT06138587

Phase1, Recruiting

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

for
Acute Myeloid Leukemia, Essential Thrombocythemia,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT04282187

Phase2, Recruiting

A Telehealth Advance Care Planning Intervention

for
Myeloid Malignancy, Acute Myeloid Leukemia,
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 60+

Code: NCT05875805

Recruiting

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

for
Haematological Malignancy, Acute Myeloid Leukemia,
Location: Philadelphia PA, Bethesda MD, Atlanta GA,
Sponsor: CellCentric Ltd.

Sex: All

Age: 18+

Code: NCT04068597

Phase1, Phase2, Recruiting

Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML

for
Acute Myeloid Leukemia (AML)
Location: New York NY, Augusta GA, Fairway KS, Houston TX,
Sponsor: Bio-Path Holdings, Inc.

Sex: All

Age: 18+

Code: NCT02781883

Phase2, Recruiting

A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications

for
Acute Myeloid Leukemia/Myelodysplastic Syndrome,
Location: Buffalo NY, Tampa FL
Sponsor: Celyad Oncology SA

Sex: All

Age: 18+

Code: NCT03018405

Phase1, Phase2, Recruiting

A Study of ADCLEC.syn1 in People With Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05748197

Phase1, Recruiting

A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 2 - 18

Code: NCT06191978

Phase1, Recruiting

A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia, in Relapse,
Location: New York NY, Houston TX, La Jolla CA, Los Angeles CA
Sponsor: Bio-Path Holdings, Inc.

Sex: All

Age: 18+

Code: NCT05190471

Phase1, Recruiting

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

for
Acute Myeloid Leukemia,
Location: Halifax, Portland ME, Scarborough ME, South Portland ME,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 59

Code: NCT05554406

Phase2, Recruiting

IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)

for
Acute Myeloid Leukemia
Location: Chapel Hill NC, Columbus OH, Dallas TX, Aurora CO
Sponsor: Alice Mims

Sex: All

Age: 18+

Code: NCT05401097

Phase2, Recruiting

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

for
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04774393

Phase1, Phase2, Recruiting

Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

for
AML, Childhood, Aml, Acute Myeloid Leukemia, Pediatric,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06158828

Phase1, Phase2, Recruiting