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Active & Responsive

Phase I/II Clinical Trial of Proteasome Inhibitor in Combination With CPX-351 for the Treatment of Newly-Diagnosed TP53-mutated Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia, TP53
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18+

Code: NCT07008638

Phase1, Phase2, Recruiting
Active & Responsive

Tagraxofusp and Low-Intensity Chemotherapy for CD123-Positive Relapsed or Refractory AML

for
Refractory Acute Myeloid Leukemia,
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 18+

Code: NCT06561152

Phase1, Phase2, Recruiting
Active & Responsive

Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

for
Acute Myeloid Leukemia
Location: Hershey PA, Cincinnati OH, Madison WI, Memphis TN,
Sponsor: Norman J. Lacayo

Sex: All

Age: 0 - 21

Code: NCT05101551

Phase1, Recruiting
Active & Responsive

Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)

for
Acute Myeloid Leukemia, Relapsed, Adult,
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18 - 65

Code: NCT06802315

Phase2, Recruiting
Active & Responsive

Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality

for
Acute Myeloid Leukemia
Location: Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06370000

Recruiting

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Active & Responsive

A Phase 1/3 Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

for
AML, MDS
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: TScan Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05473910

Phase1, Recruiting
Active & Responsive

A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis

for
Secondary AML, Myelofibrosis
Location: San Diego CA, Duarte CA, Sacramento CA
Sponsor: Aspera Biomedicines, Inc.

Sex: All

Age: 18+

Code: NCT07250646

Phase1, Recruiting
Active & Responsive

Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia

for
AML With Gene Mutations
Location: New York NY, College Park MD, Chapel Hill NC,
Sponsor: Lomond Therapeutics Holdings, Inc.

Sex: All

Age: 18+

Code: NCT06366789

Phase1, Recruiting
Active & Responsive

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for
Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver,
Location: Scarborough ME, Worcester MA, Hartford CT, Norwalk CT,
Sponsor: Massive Bio, Inc.

Sex: All

Age: 0+

Code: NCT03452774

Recruiting
Active & Responsive

Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation

for
Acute Leukemia, Myelodysplastic Syndrome
Location: Palo Alto CA
Sponsor: Laguna Biotherapeutics, Inc.

Sex: All

Age: 1 - 39

Code: NCT07573111

Phase1, Recruiting
New

Assessing PI3K Gamma Inhibition With Azacitidine, Venetoclax and Eganelisib in Patients With Acute Myeloid Leukemia

for
Leukemia, Myeloid, Leukemia, Acute Myeloid Leukemia,
Location: Boston MA
Sponsor: Jacqueline Garcia, MD

Sex: All

Age: 18 - 70+

Code: NCT07439211

Phase1, Recruiting
New

A Home-Based Exercise Intervention (CAREFit-BMT) in Improving Heart Function Among Patients With High Risk Acute Myeloid Leukemia Undergoing Stem Cell Transplant

for
Acute Myeloid Leukemia
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT07616921

Recruiting
New

A Pilot Study of Soursop Tea in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Multiple Myeloma (MM)

for
AML (Acute Myeloid Leukemia), Multiple Myeloma Refractory
Location: Camden NJ
Sponsor: Roger Strair

Sex: All

Age: 18+

Code: NCT07771803

Early_phase1, Recruiting
New

TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT

for
GVHD, Hematopoietic Cell Transplantation (HCT),
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 18 - 70+

Code: NCT07302776

Phase1, Recruiting

A Study of BTX-A51 in People With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Location: New York NY, Houston TX, Duarte CA
Sponsor: Edgewood Oncology Inc.

Sex: All

Age: 18+

Code: NCT04243785

Phase1, Recruiting

Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

for
Leukemia, High Risk Acute Lymphoblastic Leukemia,
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 0 - 25

Code: NCT06839456

Phase1, Phase2, Recruiting

Treatment of Hematologic Malignancies With Single-Unit or Double-Unit Cord Blood Transplantation

for
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia,
Location: Denver CO
Sponsor: Colorado Blood Cancer Institute

Sex: All

Age: 18 - 49

Code: NCT00328237

Phase2, Recruiting

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

for
Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12+

Code: NCT03383575

Phase2, Recruiting

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

for
Advanced Solid Tumor, TNBC - Triple-Negative Breast Cancer,
Location: New Haven CT, New York NY, The Bronx NY,
Sponsor: SillaJen, Inc.

Sex: All

Age: 18+

Code: NCT05768932

Phase1, Recruiting

Revumenib in Combination With 7+3 + Midostaurin in AML

for
Acute Myeloid Leukemia, AML, Adult, AML With Gene Mutations,
Location: Boston MA, New Haven CT
Sponsor: Richard Stone, MD

Sex: All

Age: 18 - 70+

Code: NCT06313437

Phase1, Recruiting